Fascia adherens--(FA), desmosomal--(D), and gap junctions
(nexus) (N) are situated in the intercalated disc.
Hexamers of two adjacent cells form a connexon gap junction
In order to study the formation of functional gap junctions
, we used the microinjection of Lucifer yellow (LY), a fluorescent dye which diffuses among cells through GJs .
Bedner et al., "Characterization of panglial gap junction
networks in the thalamus, neocortex, and hippocampus reveals a unique population of glial cells," Cerebral Cortex, vol.
Transient white matter lesions in X-linked Charcot-Marie-Tooth disease type 1 with novel I20T mutation of gap junction
protein beta 1 gene (in Chinese).
Global modulation mediated by gap junctions
. It has been shown that retinal gap junctions
(40,41) contribute to the neural noise reduction that is mediated by signal transmission far beyond each classical RF.
ECM-receptor interaction and gap junction
pathway were the predicted highest correlation.
Effect of PAR on Gap Junctions
. To confirm the increased level of gap junctions
evidenced in the 2D experiments, cell-to-cell communications were assessed by injecting the fluorescent dye, lucifer yellow (LY), in the 3D model after PAR treatment (Figure 7).
For these reasons, all anti-apoptotic treatment modalities such as a Ca-sensitiserinotropic agent levosimendan, caspase and/or Poly (ADP-ribose) polymerase (PARP) inhibition, inhibition of Bax using antisense technology, adenine nucleotide transporter (ANT) antibodies, gap junction
and microtubule inhibitors in the treatment of myocardial ischaemia/ reperfusion injury can individually exert beneficial therapeutic effects.
Global Markets Direct's, 'Connexin (Gap Junction
Protein) - Pipeline Review, H1 2016', provides in depth analysis on Connexin (Gap Junction
Protein) targeted pipeline therapeutics.
Fluorescence recovery after photobleaching (FRAP) is a noninvasive technique that allows quantitative measurement of gap junction
function in living cells.
In a past study, the concentrations of metaloproteinase-3 in the supernatant of cultured synovia from patients with RA were decreased by adding a gap junction