gap junction


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gap junction

[′gap ‚jəŋk·shən]
(neuroscience)
An intercellular junction composed of cylindrical channels connecting adjacent cells; considered to be a low-resistance pathway for intercellular communication. Also known as communicating junction; nexus.
References in periodicals archive ?
Hexamers of two adjacent cells form a connexon gap junction. Permeable
In order to study the formation of functional gap junctions, we used the microinjection of Lucifer yellow (LY), a fluorescent dye which diffuses among cells through GJs [30].
Bedner et al., "Characterization of panglial gap junction networks in the thalamus, neocortex, and hippocampus reveals a unique population of glial cells," Cerebral Cortex, vol.
Transient white matter lesions in X-linked Charcot-Marie-Tooth disease type 1 with novel I20T mutation of gap junction protein beta 1 gene (in Chinese).
Global modulation mediated by gap junctions. It has been shown that retinal gap junctions (40,41) contribute to the neural noise reduction that is mediated by signal transmission far beyond each classical RF.
ECM-receptor interaction and gap junction pathway were the predicted highest correlation.
Effect of PAR on Gap Junctions. To confirm the increased level of gap junctions evidenced in the 2D experiments, cell-to-cell communications were assessed by injecting the fluorescent dye, lucifer yellow (LY), in the 3D model after PAR treatment (Figure 7).
For these reasons, all anti-apoptotic treatment modalities such as a Ca-sensitiserinotropic agent levosimendan, caspase and/or Poly (ADP-ribose) polymerase (PARP) inhibition, inhibition of Bax using antisense technology, adenine nucleotide transporter (ANT) antibodies, gap junction and microtubule inhibitors in the treatment of myocardial ischaemia/ reperfusion injury can individually exert beneficial therapeutic effects.
Global Markets Direct's, 'Connexin (Gap Junction Protein) - Pipeline Review, H1 2016', provides in depth analysis on Connexin (Gap Junction Protein) targeted pipeline therapeutics.
Fluorescence recovery after photobleaching (FRAP) is a noninvasive technique that allows quantitative measurement of gap junction function in living cells.
In a past study, the concentrations of metaloproteinase-3 in the supernatant of cultured synovia from patients with RA were decreased by adding a gap junction blocker (heptanol).