gene duplication


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gene duplication

[′jēn düp·lə′kā·shən]
(genetics)
The reduction in fitness of a diploid population due to new mutant genes and those already in the gene pool.
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References in periodicals archive ?
Nevertheless, the data show that the aquaporin grades independently expanded by gene duplication in the different lineages.
Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse.
Evidences of natural selection suggest that gene duplications in paralogous copies of beta-globin genes evolve under a non-episodic process of functional divergence (28).
Most of these methods are based on PCR (19-24) or real-time gPCR (25), but most fail to detect CYP21A2 gene duplications (21, 23, 25), a shortcoming that can lead to misidentification of a nonpathological allele with 2 CYP21A2 genes, 1 mutated plus 1 wild type, as a pathological 21OHD allele (12).
A paralogue is the gene that has the closest DNA sequence to another gene, probably because the two arise via gene duplication.
Little wonder that Philippe and Forterre (73) found the phylogenies as highly confusing due to the combining effects of gene duplication, gene loss, lateral gene transfer, etc.
Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication
Gene duplication is often mediated by a mechanism called retrotransposition, whereby a gene is duplicated at a new location thanks to the action of genetic elements called retrotransposons.
Our large, high-quality dataset and the naturally high frequency of these gene duplications in Arabidopsis allowed us to make such an analysis for the first time.
The large increase in the gene duplication rate continued into the common ancestor of humans and chimpanzees.
He begins with basic issues such as plant hormones and the cytoskeleton of plant cells and progresses to phylogeny, taxonomy, gene duplication, the regulation of gene expression and systems biology.
Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease: Lancet 364(9440):1169-1171.