gene scanning

gene scanning

[¦jēn ‚skan·iŋ]
(cell and molecular biology)
A method by which mutations are inserted at specific sites on a deoxyribonucleic acid (DNA) segment to determine those DNA sequences needed for gene activity.
References in periodicals archive ?
Gene scanning and genotyping with snapback primers requires only 2 primers, symmetric PCR with a saturation dye, and high-resolution melting.
Prior to this position he served as Vice President for Research and Development at 20/20 GeneSystems, a biotechnology company that develops and commercializes innovative diagnostic products based on the patented Layered Gene Scanning platform, for which he contributed to securing private and Federal research funding.
The more useful information that gene scanning can provide today is how we will likely react to various pharmaceuticals.
With support from the National Institutes of Health, researchers found those mutations through whole exome sequencing -- a new gene scanning technology that cuts the cost and time of searching for rare mutations.
This analysis method improves the resolution, through-put and ease of high resolution nucleic acid melting techniques and broadens its appeal for expanded use in gene scanning, mutation discovery, and genotyping applications.
Because gene scanning depends on melting curve differences created by mismatched bases, it is not always feasible to detect homozygous mutations when a gene-scanning protocol is used.
Access to Sigma-Aldrich's MISSION shRNA libraries will greatly enhance our current gene scanning capabilities and will enable us to discover and validate cancer-causing genes and pathways which will hopefully lead to novel approaches to therapeutic intervention for cancer patients.
As the new gene scanning software module was only recently made available on the LightCycler 480, we were able to find data from only one other study (9) comparing the results of both instruments for factor VIII mutations.
This marks the first time that an isolator system for TB can go directly from isolation to antibiotic resistance gene scanning with technology that is user friendly.
Recently, high-resolution melting analysis was introduced as a simple, closed-tube, gene scanning technique (13).
Aimed at anticipating disease onset and predicting disease progression, Avitech's products combine genome science with powerful gene scanning technology.
Fragments 1, 2, and 4 provided adequate coverage for gene scanning, and fragment 3 was designed to test for mutations close to the primer.