Genetic Polymorphism


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Related to Genetic Polymorphism: Single nucleotide polymorphism

Genetic Polymorphism

 

the coexistence within a population of two or more different hereditary forms, which are in dynamic equilibrium for several or even many generations. Genetic polymorphism is most often caused either by the varying pressures and vectors (direction) of selection under different conditions (for example, at different seasons) or by the increased relative viability of heterozygotes. One type of genetic polymorphism—balanced genetic polymorphism—is characterized by a constant optimal correlation between polymorphic forms, deviation from which proves unfavorable for the species. Balanced genetic polymorphism regulates itself automatically (an optimal correlation of forms is established). The majority of genes in man and animals are in a state of balanced genetic polymorphism. Several forms of genetic polymorphism may be distinguished; analysis of these forms makes it possible to determine the effect of selection in natural populations.

REFERENCE

Timofeev-Resovskii, N. V., and Iu. M. Svirezhev. “O geneticheskom polimorfizme v populiatsiiakh.” Genetika, 1967, no. 10.
References in periodicals archive ?
Tanaka et al., "Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans," Clinical Pharmacology and Therapeutics, vol.
The results could provide details of the association of genetic polymorphisms and H.
CYP3A4*1G genetic polymorphism influences metabolism of fentanyl in human liver microsomes in Chinese patients.
In the same study, no significant difference was seen between the SAP and MAP patients in terms of genetic polymorphism (25).
(8) examined the correlation between glottic laryngeal cancer and genetic polymorphism. This study compared the polymorphic variants of C1772T and G1790A of HIF1[alpha] in glottic laryngeal cancer patients versus healthy volunteers.
(13,14) Genetic polymorphisms may affect gene expression and circulating levels of IL-18 and thereby modify the risk of CAD.
Genetic polymorphism analysis of the [beta]-lactoglobulin revealed the presence three genotypes (AA, AB and BB) and two allelic variants (A and B) in Pramenka breed.
Jiang, "Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL-1 receptor antagonist (IL-1RN) and prostate cancer risk," Asian Pacific Journal of Cancer Prevention, vol.
Besides determination of the full nucleotide sequence of the American mink growth hormone gene, sequencing aimed at detecting genetic polymorphisms within the gene and direct genotyping.
The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements in an adult Turkish population.
Further, this study hypothesized that the genetic polymorphism of STK11 will influence the metformin efficacy in treating Chinese T2DM patience.