gentisic acid


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gentisic acid

[jen′tis·ik ′as·əd]
(organic chemistry)
C7H6O4 A crystalline compound that forms monoclinic prisms from a water solution, sublimes at 200°C, melts at 250°C, and is soluble in water, alcohol, ether, sodium, and salt; used in medicine. Also known as gentianic acid.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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The [sup.89]Zr-labeled mAbs were purified on PD-10 columns eluted with acetate buffer (pH 5.5) containing gentisic acid at 5 mg/ml.
Phenolic content of green tea extracts (mg phenolic/kg plant) Phenols CH[Cl.sub.3] EtOAc n-BuOH extract extract extract Gallic acid 0.25 777.93 1344.96 Gentisic acid 0.15 ND 102.14 Catechins 0.04 174.95 ND Chlorogenic acid ND 2.37 21.18 4-Hydroxybenzoic acid 0.31 ND 1.8 Protocatechuic acid 0.03 2.49 3.51 Caffeic acid 0.04 7.43 5.66 Vanillic acid 5.00 46.31 20.04 4-Hydroxybenzaldehyde 0.3 0 ND Rutin 0.11 22.2 646.29 p-Coumaric acid 0.70 15.00 4.18 Ellagic acid 0.51 0.85 1.35 Chicoric acid ND 0.2 0.67 Ferulic acid ND ND 1.92 Hesperidin ND 0.65 2.5 Apigenin 7-glucoside ND 0 1.96 Rosmarinic acid 0.03 0.237 ND Protocatechuic acid ND 0.05 0 ethyl ester Salicylic acid 6.5 34.69 21.23 Resveratrol ND ND 0.08 Quercetin 0.71 ND ND Naringenin 0.08 0.35 ND Kaempferol ND ND 0.43 ND: not detected.
The antibacterial activity exerted by both extracts might be attributed to the presence of bioactive constituents such as catechin, rutin and apigenin, gallic acid, gentisic acid cinnamic acids detected by HPLC-TOF/MS.
Methanol extract Aqueous extract Coumpounds RT Concentration Concentration mg/kg CS mg/kg CS Gallic acid 2.051 122.26 383.20 Gentisic acid 4.386 45.46 18.03 Catechin 6.139 899 143.15 4-hydroxy 6.123 3.882 -- benzoic acid Protocatechuic 6.982 19.96 9.869 acid Rutin 9.496 211.253 45.95 Ferullic acid 11.164 9.121 -- Apigenin-7- 12.303 11.697 -- glucoside Cinnamic acid 15.703 66.526 -- Table 3: Antibacterial activity of Cistus salvifolius methanol and aqueous extracts against Gram-positive and Gram-negative bacteria.
Studies with labeled aspirin showed that applied aspirin to cotyledons is converted to salicylic acid and gentisic acid (2, 5-dihydroxybenzoic acid) (Groenewald, 1981).
In one experiment where arachidonic acid, [PGE.sub.1], gentisic acid, acetylsalicylic acid, salicylic acid, and oleic acid were applied to excised shoot apices under inductive conditions (short days), it was found that arachidonic acid and [PGE.sub.1] hastened flower formation by 29 days and 28 days, respectively, as compared with controls.
Furthermore, three compounds, protocatechuic acid/ gentisic acid, vanillic acid, and myricetin corresponding to m/z 155,169, and 319, respectively, have been observed in CP plant but not detected in CA plant.
2,2-Diphenyl-1-picrylhydrazy* (DPPT*), standards of gentisic acid, (+)-catechin, (+)-gallocatechin, aesculin, (-)-epigallocatechin, p-hydroxybenzoic acid, protocatechuic acid, (-)-epicatechin, (-)-gallocatechin gallate, rutin, ellagic acid, naringin, (-)-epigallocatechin gallate, myrcetin, quercetin, naringenin, luteolin, chrysin, pinocembrin, galangin, trans-resveratrol, apigenin, and hesperetin were purchased from Fluka AG (Buch, Switzerland).
It has been reported that administration of phenolic acids (i.e., gentisic acid, gallic acid, ferulic acid, and pcoumaric acid) at a dosage of 100 mg/kg for 14 consecutive days in rats enhanced the mRNA expression of hepatic CuZn-SOD, GPx, and catalase [10].
RT (min) Name Peak area Concentration ([micro]C) 15.29 Protocatechuic acid 6.98 10.11 25.83 Gentisic acid 8.78 7.64 33.13 Chlorogenic acid 2.30 8.17 35.97 Vanillic acid 3.08 1.34 37.65 Caffeic acid 66.10 27.56 42.25 Epicatechin 2.20 5.11 46.67 p-Coumaric acid 19.50 169.81 49.78 Ferulic acid 7.05 13.21 50.43 Sinapic acid 6.41 4.68 75.35 Quercetin 128.0 399.00 RT: retention time.