germline

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Related to germ line: germ layer, Germline mutation

germline

[′jərm ‚līn]
(biology)
A lineage of cells from which gametes are derived. Also known as germ track.
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References in periodicals archive ?
Be that as it may, further molecular research is needed to precisely identify the synergy between the different types of cell death in the female germ line.
Mutations of the p53 gene in canine lymphoma and evidence for germ line p53 mutations in the dog.
While this approach is successful at identifying targeted small-molecule therapies for up to 40% of patients, depending upon tumor type, information relevant to predicting response to checkpoint blockade inhibitors is obtained only when several hundred genes are queried, and germ line variants are only inferred, requiring a second, focused test from a matched normal tissue to confirm.
Prof Charpentier, director of the Max Planck Institute for Infection Biology in Berlin, said: "I'm worried about the use of the technology for editing human germ lines and designer babies.
Prof Charpentier, director of the Max Planck Institute for Infection Biology, in Berlin, said: "I'm worried about the use of the technology for editing human germ lines and designer babies.
Though gene-editing tools have the power to potentially cure a number of diseases, scientists have proceeded cautiously, in part to avoid introducing unintended mutations into the germ line (cells that become eggs or sperm).
[5.] Thompson S, Clarke AR, Pow AM, Hooper ML, Melton DW Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.
Spatial Variations in the MLV-ERV Landscapes among Germ Line and Somatic Genomes in a Single C57BL/6J Inbred Mouse.
Recently, however, the ethics committee of the Biomedical Research Agency of France (INSERM) set out its position about it and recommended the prohibition of all genetic modifications of the germ line (13).
The genomic landscape of localised prostate cancer has been well defined, describing putative pathogenic BRCA2 germ line mutations as well as somatic and germ line DNA repair alterations found such as BRCA1, CDK12, FANCA, and RAD51B.
These genes also tend to be active in the germ line (eggs and sperm and the cells that give rise to them).