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Related to Germinal center: lymph node, mantle zone


in politics, a party following a middle course. The term was first used in France in 1789, when the moderates of the National Assembly sat in the center of the hall. It can refer to a separate party in a political system, e.g., the Catholic Center party of imperial and Weimar Germany, or to the middle group of a party consisting of several ideological factions.



in machine building, a device used to position a work-piece or mandrel on lathes, rotary grinders, and other machine tools, as well as on checking and measurement instruments.

One end of a center has a working conical surface with a vertex angle of 60° or 90°; the other has a shank with a shallow cone used to secure the center in the headstock spindle or tailstock spindle, which is an axially adjustable sleeve. If it is necessary to bore the end face of a workpiece, an opening is provided on the dead center so that a cutting tool may protrude. Machining of hollow workpieces calls for larger-diameter centers in the shape of truncated cones that fit into a conical, chamfered hole in the workpiece. Live centers, which are set in the spindle of the machine tool, have serrations on a conical working surface to transmit motion to the workpiece. In order to prevent slippage of the workpiece at higher machine speeds, the dead center may be replaced with a live center running on roller bearings. Centers are fabricated from hardened steel.



in mathematics. (1) A point O is said to be the center of symmetry of a geometric configuration if for every point A of the configuration there is another point A′ of the configuration such that O is the midpoint of the line joining A and A′. A curve or surface that has such a center is said to be central. The circle, ellipse, and hyperbola are the simplest examples of central curves, and the sphere, ellipsoid, and hyperboloid (of one or two sheets) are the simplest examples of central surfaces. It is possible for a configuration to have infinitely many centers of symmetry; for example, the centers of symmetry of a configuration consisting of two parallel lines lie on the line equidistant from the two given lines. (See alsoSYMMETRY.)

Figure 1

(2) The center of similitude of radially related configurations is the point S at which lines joining corresponding points of the configurations intersect (Figure 1).

Figure 2

(3) If all integral curves in the neighborhood of a singular point of a differential equation are closed and enclose the singular point, that point is said to be a center (Figure 2). Centers belong to the class of singular points whose character generally is not preserved when small changes are made in the right-hand side of the equation.


(industrial engineering)
A manufacturing unit containing a number of interconnected cells.
The point that is equidistant from all the points on a circle or sphere.
The point (if it exists) about which a curve (such as a circle, ellipse, or hyperbola) is symmetrical.
The point (if it exists) about which a surface (such as a sphere, ellipsoid, or hyperboloid) is symmetrical.
For a regular polygon, the center of its circumscribed circle.
The subgroup consisting of all elements that commute with all other elements in a given group.
The subring consisting of all elements a such that ax = xa for all x in a given ring.
To adjust the components of an optical system so that their centers of curvature lie on a common optical axis. Also known as square-on.
For a distribution, the expected value of any random variable which has the distribution.


1. The center ply in plywood.
2. The core in a laminated construction.
3. Centering.
4. The center about which an arc of a circle is drawn, equidistant from all points on the arc.


(US), center
1. Geometry
a. the midpoint of any line or figure, esp the point within a circle or sphere that is equidistant from any point on the circumference or surface
b. the point within a body through which a specified force may be considered to act, such as the centre of gravity
2. the point, axis, or pivot about which a body rotates
3. Politics
a. a political party or group favouring moderation, esp the moderate members of a legislative assembly
b. (as modifier): a Centre-Left alliance
4. Physiol any part of the central nervous system that regulates a specific function
5. a bar with a conical point upon which a workpiece or part may be turned or ground
6. a punch mark or small conical hole in a part to be drilled, which enables the point of the drill to be located accurately
7. Basketball
a. the position of a player who jumps for the ball at the start of play
b. the player in this position
8. Archery
a. the ring around the bull's eye
b. a shot that hits this ring
References in periodicals archive ?
(a) Negative in the lesional cells but highlights the associated reactive germinal centers. (b) Light-chain restriction can be demonstrated in the plasma cell population, which helps to differentiate from B-cell pseudolymphoma.
The reactive lymphoid follicles comprise germinal centers with polarity and tingible-body macrophages, and the germinal centers are surrounded by the mantle zone with small mantle cells; the marginal zone with monocytoid lymphocytes is located outside of the mantle zone in the parafollicular area and is usually not prominent in the lymph nodes.
The germinal centers often have a starry-sky appearance because of the relatively numerous tingible-body macrophages and mitotic figures present.
A primary follicle (red circle) is positive for BCL2 (D) but shows no staining for germinal center markers CD10 (C) or BCL6 (not shown).
Suzuki et al., "Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers," Journal of Experimental Medicine, vol.
Furthermore, there were some regressive germinal centers, exhibiting features of Castleman disease in the adjacent lymph node parenchyma.
Bone marrow derived naive B cells ingress into the lymph node and enter a germinal center reaction, after antigen stimulation, where they proliferate rapidly and undergo class switching and somatic hypermutation [22].
Photomicrograph showing mucosal glands entering lymphoid tissue of proximal colon of 6 month old buffalo calf by disintegration of lamina muscularis mucosae, lymphoid nodules with germinal center (GC), without GC (stars), lymphoglandular complex (LGC) also without GC and is enclosed by its own lamina muscularis mucosae (dotted arrow) (Haematoxylin and Eosin X40).
Hyalinized small blood vessels penetrating follicular germinal centers are characteristic of HV-CD.26 Ultrasound guided FNAC is more accurate and less traumatic than lymph node biopsy.27 However according to other reports there is limited role of FNA in the diagnosis of this condition although physicians are still encouraged to advise FNA in cases of persistent neck swellings to rule out other conditions.28
In fact, without Tfh cells, germinal center do not develop, long-lived plasma cells are not generated, and long-term antibody responses are impaired (7).
Both SNPs seem plausible --interleukin-10 induces the bcl-2 protein, which prevents the spontaneous death of germinal center B cells, and some evidence has linked HLA polymorphisms to DLBCL, Dr.