The predominance of lymph node metastasis seems to be characteristic of ependymoma tumors contrary to medulloblastomas or germinomas
for which bones and visceral organs are mostly involved .
 Thus, in the present study with the normal levels of serum AFP and B-hCG, the CD117 positive extragonadal germinoma
was proved to be of thymic origin because of the negativity for CK.
It has also been found that KIT is frequently mutated in intracranial germinomas
; however, this finding may be an independent mechanism that helps to drive RAS signaling in Type II GCTs rather than an aberration of normal developmental pathways as would be the case in KITLG-mediated PGC proliferation .
and mature teratomas have the best prognosis.
Also other etiologies such as Langerhans cell histiocytosis [LCH] are indiscernible from a germinoma
by MRI [17, 18].
presenting as a first psychotic episode in an adolescent male.
Cameron Aspery was diagnosed with a rare brain tumour, called a germinoma
, at the age of 18 after experiencing symptoms including memory loss, severe fatigue and headaches.
O presente trabalho relata o caso de uma adolescente do sexo feminino, com 14 anos de idade e diagnostico de germinoma
de sistema nervoso central em regiao suprasselar, em tratamento no Instituto Nacional de Cancer Jose de Alencar Gomes da Silva.
Mallucci et al., "Intraabdominal metastasis of an intracranial germinoma
via ventriculo-peritoneal shunt in a 13-year-old female," British Journal of Neurosurgery, vol.
Bifocal intracranial germinoma
: a retrospective analysis of treatment outcomes in 20 patients and review of the literature.
Differential diagnosis to be considered in a patient with cerebral hemiatrophy include Sturge-Weber syndrome, Rasmussen encephalitis, Silver-Russel syndrome, and basal ganglia germinoma
. Conditions associated with unilateral megalencephaly, as in the linear nevus syndrome, should also be considered.
Because of the limited number of cases, the treatment of adrenal germinoma
has not been established yet.