germline


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germline

[′jərm ‚līn]
(biology)
A lineage of cells from which gametes are derived. Also known as germ track.
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Tomsic et al., "Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations," Gastroenterology, vol.
Both somatic mutations and germline variants were searched in COSMIC (Catalog of Somatic Mutations in Cancer; http://cancer.
That said, given safety and ethical issues, the statement also argued that at this time it is still "inappropriate to perform germline gene editing that culminates in human pregnancy."
However, in the presence of a cancer predisposition syndrome (germline mutation in a known cancer predisposition gene), significant family history, or prior personal history of ionizing radiation to the chest, consideration may be given to screening breast MRI.
Second, germline engineering is controversial in itself.
They also said It would be "irresponsible" to edit the human germline, until the safety issues had been resolved.
Generally, the inheritance of a defective BRCAl or BRCA2 allele (a germline mutation) alone is not enough to cause the development of cancer.
Deliberate germline editing should not be pursued until safety and efficacy issues have been resolved, and there is broad societal consensus that such editing is appropriate.
Before this treatment can be applied to humans, researchers need to know the mechanism of female germline stem cell development and safety after transplantation of single mouse female germline stem cells.
as a monotherapy in patients with deleterious or suspected deleterious germline BRCA-mutated advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy.
But moral, ethical and safety concerns would make it "irresponsible" to proceed with clinical studies in germline cells--eggs, sperm, embryos and other cells that transmit DNA to future generations, the statement added.
The issue is whether to use the technique to alter human eggs, sperm or early embryos in ways that would be passed on, a process that is called germline editing.