gist


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gist

Law the essential point of an action
References in classic literature ?
That has been the gist of the parables which I have tried to adapt to the comprehension of my parishioners."
Here's the gist of the matter in two words: you are to rise on tiptoe, as I tell you; in that way you will be able to reach the pocket of the manikin, you will rummage it, you will pull out the purse that is there,--and if you do all this without our hearing the sound of a bell, all is well: you shall be a vagabond.
"Ah, now we come to the gist of the matter," Ernest said with a pleased expression.
The gist of them was that thus far we had remarkably little to show for what Raffles would call "our second innings." This even I could not deny.
This stand-alone registrational bridging study in China includes a Phase I dose-escalation study and Phase II dose-expansion study, with the aim of evaluating the safety, pharmacokinetics and efficacy of avapritinib in patients with unresectable or metastatic gastrointestinal stromal tumors (GIST).
In addition to the INVICTUS data, Deciphera will also be submitting in its NDA supportive data from the ongoing Phase 1 clinical study, which will include the updated data from GIST patients at doses of >100mg of ripretinib.
The "Market Spotlight: Gastrointestinal Stromal Tumor (GIST)" report has been added to ResearchAndMarkets.com's offering.
c-kit-mutated GIST. Almost 75% of all GISTs present gain-of-function mutations in the KIT gene in exons 11, 9, 13, and 17, which activate downstream pathways (RAS/RAF/MAPK, JAK/STAT3, and PI3K/AKT/mTOR), increasing proliferation or evading apoptosis.
However, there are no reports on the biological function of CCDC26 in imatinib resistance in GIST.
The US State Department runs the annual GIST competition that aims to empowers young innovators through networking, skills building and access to financing to develop startup solutions.
Subsequently, her histopathology reports suggested high-grade spindle cell variant of GIST with CD-117 positivity and Ki67 indexing label of 10%.