globulin


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globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.
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Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Additionally, we found that that globulin and prolamins fractions may have antithrombotic and opioid peptides, respectively, which can act as platelet aggregation inhibitors and powerful painkiller [14, 39].
In the past, serum sex hormone-binding globulin (SHBG) was considered to be a way for the storage of sex hormones only.
Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors.
Type 2 Diabetes Mellitus and Sex Hormone-Binding Globulin
DISCUSSION: E.S.R, Serum total protein, Serum albumin, Serum globulin and RBC count are indicators of the health and nutritional status of females, which in turn affects its reproductive capability.
There was a significant reverse correlation between level of Sex Hormone Binding Globulin in blood and being a case of preeclampsia (adjusted odds ratio=0.99; 95% Confidence Interval: 0.98, 1.00; p=0.04).
Supplemental questions related to laboratory testing for weak D and administration of Rh immune globulin were included in the CAP 2012 J-B Transfusion Medicine (Comprehensive) survey.
Hepatitis B immune globulin was administered at birth and hepatitis B vaccine was given at birth and at one, two, four, and six months.
Abbreviations ATN: Acute tubular necrosis BMI: Body mass index BPAR: Biopsy-proven acute rejection CMV: Cytomegalovirus CNI: Calcineurin inhibitor CsA: Cyclosporine DCD: Donation after circulatory death DGF: Delayed graft function dnDSA: De novo donor specific antibodies DSA: Donor specific antibodies ECD: Expanded criteria donor IRI: Ischemia-reperfusion Injury IL-2RA: Interleukin-2 receptor antagonist L-FABP: L-type fatty acid binding protein MFI: Mean fluorescence intensity MMF: Mycophenolate mofetil NAGL: Neutrophil gelatinase-associated lipocalin OPTN: Organ Procurement and Transplant PRA: Panel reactive antibody PTLD: Posttransplant lymphoproliferative disease rATG: Rabbit antithymocyte globulin (Thymoglobuline).
All samples were processed for donor recipient crossmatch using routine incubation CDC, extended incubation CDC and antihuman globulin CDC.
The value of AGR is calculated with albumin and globulin, which are not only the two main constituents of serum protein that maintain osmotic pressure but also are affected by the nutritional status and systemic inflammation.
Serum albumin, 64%; alpha-1 globulin, 6.11%; alpha-2 globulin, 8.74%; beta globulin, 14.7%; and gamma globulin, 6.4% levels were detected with protein electrophoresis.