globulin


Also found in: Dictionary, Thesaurus, Medical, Financial, Wikipedia.

globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
..... Click the link for more information.
 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information.
). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
..... Click the link for more information.
, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
..... Click the link for more information.
, and inorganic ions.

Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
In addition, 103 of these samples had been processed using routine incubation CDC, and 111 using anti-human globulin CDC (Figure 1).
In the past, serum sex hormone-binding globulin (SHBG) was considered to be a way for the storage of sex hormones only.
In this study, there is decrease in serum globulin levels compared to matched controls in all three trimesters.
It is necessary to conduct studies for evaluating the serum proteins of the Morada Nova sheep, especially by the electrophoretic separation of the protein fractions for better understanding of the changes occurring in the globulin levels.
The percentages of transfusion services that routinely recommended administration of Rh immune globulin to patients with the weak D phenotype who were transfused with various blood components from Rh-positive donors are listed in Table 2.
An overall comparison of serum gamma globulin levels of healthy subjects, newly diagnosed breast cancer patients and the patients undergoing chemotherapy was performed.
These recommendations reflect the ACIP work group discussions and review of scientific evidence related to use of varicella zoster immune globulin conducted during the development of the ACIP statements on prevention of varicella as well as a review of published literature to include reports with immune globulins with high anti--varicella-zoster virus antibodies used outside the United States >4 days after exposure to varicella-zoster virus.
Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: the "Coronary Artery Risk Development in Young Adults" women's study.
When the present results are compared to those described for Boa constrictor constrictor (Chiodini and Sunberg, 1982), lower albumin and similar globulin levels are found in both seasons.
10 One of the main functions of these cells is to produce thyroid binding globulin, albumin and pre albumin.
The pharmaceutical industry is complaining that the Ministry of Public Health has not done enough to remove fake medicines from the market, despite efforts to confiscate fake Human Gamma Globulin from pharmacy shelves, reports Listin Diario (Feb.
Hepatitis A vaccine versus immune globulin for postexposure prophylaxis.