E) 5HPO group showed mild congestion at the glomerulus
There are many valuable uses for this protocol of mature podocyte generation, including investigating the steps involved in the differentiation of podocytes from their progenitor cells (a process which remains largely unknown); studying the source and progression of various kidney diseases including podocyto-pathies and glomerulosclerosis; and establishing in vitro systems for kidney drug testing and discovery, such as the Glomerulus
Cases were randomly assigned to each of the 5 scoring pathologists, with overlap such that each glomerulus
would have at least 2 sets of scores to evaluate interpathologist reproducibility.
By increasing the accuracy of glomerulus
detection and reducing the number of candidate locations, it is expected to accelerate the research of kidney diseases and the development of the diagnosis system based on glomeruli detection.
The metaplasia was visualised as a change from flattened parietal epithelium to cuboidal epithelium lining the glomerulus
. The segmental glomerulosclerosis was visualised as glomeruli that showed scarring of small sections of the glomeruli, while global glomerulosclerosis was visualised as totally scarred glomeruli.
For confirmation of the mesangial proliferative glomerulonephritis by inducing ethanol intake and restraint stress, the number of the mesangial cells was counted in the 65 glomerulus
of the kidney.
Only one glomerulus
was globally sclerotic, and none showed segmental scars.
* Number of glomerulus
in the biopsy cores ranged from 5 to 22 with a mean of 12 [+ or -] 4.7.
Where non-proliferative pattern is characterized by the form of GN in which the number of cells per glomerulus
are not increased or the total number of cells remain the same.
Finally, this abnormal deposition of immune complexes in the glomerulus
causes local inflammation, mesangial proliferation, matrix expansion, and eventually fibrosis, while endocapillary proliferation and extracapillary proliferation are more rare findings .
For quantification of desmin, podocin, and 8OHdG in the glomeruli, the percentage of positive area was determined as positive pixels per total pixels in a glomerulus
using Image Scope software.