A high amount of amylolitic bacteria may increase the production of pronionic acid (NUSSIO et al., 2006) which, after being absorbed by the ruminal wall, goes to the liver and metabolized until it is transformed into glucose through glucogenesis
(O'CALLAGHAN; BOLAND, 1999).
In the liver, several important pathways play a role in glucose homeostasis by maintaining a balance between glucose uptake and storage that is determined by glucogenesis
and glycolysis, as well as glucose release that is regulated by glycogenolysis and gluconeogenesis (Baquet et al., 1990).
The additional protein calories via glucogenesis
may have provided additional substrate for glycogen resynthesis to occur, therefore aiding in an enhanced recovery.
Agent Comment Metformin Increased insulin sensitivity, reduction of glucogenesis
, inhibition of excessive glucose absorption, enhanced glycolysis by increasing gene expression that encodes for glucokinase and liver-specific pyruvate kinase.