glucokinase


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glucokinase

[¦glü·kō′kī‚nās]
(biochemistry)
An enzyme that catalyzes the phosphorylation ofD-glucose to glucose-6-phosphate.
References in periodicals archive ?
growth hormone (gh), growth hormone receptor (ghr), insulin-like growth factor 1 (igf-1), insulin-like growth factor receptor (igf-1r), insulin-like growth factor binding protein 1 (igfbp-1), ghrelin (ghrl), cholecystokinin (cck) and glucokinase (gck), thyroglobulin (tg).
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.
A drug targeting glucokinase could prevent obesity, the scientists believe.
Biotin Increases Pancreatic Glucokinase expression via soluble guanylate cyclase/ protein kinase G and autocrine feedback action of insulin.
Biotin increases pancreatic glucokinase expression via soluble guanylate cyclase/protein kinase G and autocrine feedback action of insulin.
Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.
However, a review article revealed several mechanisms which include enhanced hepatic glucose uptake via activation of glucokinase and promotes synthesis and storage of glycogen via activation of glycogen synthase in the liver, another mechanism is that glucose and fructose might exert a synergistic effect in the intestine and pancreas.
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Glucokinase expression at both transcriptional and translational levels is regulated by biotin in the liver and pancreas.
82,83) Additionally, fructose has also been shown to stimulate glucokinase in hepatocytes which plays a significant role in the uptake and storage of glucose (as glycogen) by the liver.
These injections introduce gene therapy vectors, with a dual objective: to express the insulin gene, on the one hand, and that of glucokinase, on the other.