Comparison of
Glucolipid Metabolism Disorders among Juvenile Female Offspring in Four Models
Uncoupling protein 2 (UCP2), which is widely expressed in human tissues and serves as an uncoupler of oxidative phosphorylation, is involved in the regulation of
glucolipid metabolism and ATP production [1, 2].
The results showed that under the low concentration of PA stimulation, the high expression level of KLF4 could improve the
glucolipid metabolism ability.
Nevertheless, the TZD class of peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) agonists is one major and important therapeutic that directly targets insulin resistance by protecting pancreatic [beta]-islet cells, dysregulated transcription program on
glucolipid modulation, and imparting anti-inflammatory protection.
The results showed that Tangzhiqing granules could regulate
glucolipid metabolic disorders and relieve diabetic nephropathy.
Activation of b2 receptors can maintain normal trachea relaxation and
glucolipid metabolism.
AMP-activated protein kinase (AMPK), the energy-sensing enzyme, plays an important role in
glucolipid metabolism (Friedrichsen et al.
Recently, some researches reported that metformin (1,1-dimethylbiguanide), as the first-line hypoglycemic drugs for the treatment of T2DM, can prevent and delay the occurrence and progress of diabetic nephropathy through some mechanisms, which include improving
glucolipid metabolism, improving insulin resistance, and some other nonhypoglycemic action mechanisms [6].
Thiazolidinediones (rosiglitazone or pioglitazone) have been shown to improve steatosis and liver enzyme levels and regulate
glucolipid metabolism.
Zhang et al., "Chronic effects of berberine on blood, liver
glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats," Biological and Pharmaceutical Bulletin, vol.