Comparison of Glucolipid
Metabolism Disorders among Juvenile Female Offspring in Four Models
Uncoupling protein 2 (UCP2), which is widely expressed in human tissues and serves as an uncoupler of oxidative phosphorylation, is involved in the regulation of glucolipid
metabolism and ATP production [1, 2].
The results showed that under the low concentration of PA stimulation, the high expression level of KLF4 could improve the glucolipid
Nevertheless, the TZD class of peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) agonists is one major and important therapeutic that directly targets insulin resistance by protecting pancreatic [beta]-islet cells, dysregulated transcription program on glucolipid
modulation, and imparting anti-inflammatory protection.
The results showed that Tangzhiqing granules could regulate glucolipid
metabolic disorders and relieve diabetic nephropathy.
Activation of b2 receptors can maintain normal trachea relaxation and glucolipid
AMP-activated protein kinase (AMPK), the energy-sensing enzyme, plays an important role in glucolipid
metabolism (Friedrichsen et al.
Recently, some researches reported that metformin (1,1-dimethylbiguanide), as the first-line hypoglycemic drugs for the treatment of T2DM, can prevent and delay the occurrence and progress of diabetic nephropathy through some mechanisms, which include improving glucolipid
metabolism, improving insulin resistance, and some other nonhypoglycemic action mechanisms .
Thiazolidinediones (rosiglitazone or pioglitazone) have been shown to improve steatosis and liver enzyme levels and regulate glucolipid
Zhang et al., "Chronic effects of berberine on blood, liver glucolipid
metabolism and liver PPARs expression in diabetic hyperlipidemic rats," Biological and Pharmaceutical Bulletin, vol.