gluconeogenesis


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Related to gluconeogenesis: Cori cycle

gluconeogenesis

[¦glü·kō¦nē·ō′jen·ə·səs]
(biochemistry)
Formation of glucose within the animal body from substances other than carbohydrates, particularly proteins and fats.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Glucagon promotes the capacity of hepatic gluconeogenesis in early lactating cows [26].
This would decrease the availability of glycerol, increase the shift of pyruvate to gluconeogenesis, and decrease the release of pyruvate by the liver.
G6Pase is an enzyme in gluconeogenesis and glycogenolysis, which plays a key role in the homeostatic regulation of blood glucose levels (Nordlie and Sukalski, 1985).
Rahimi et al., "Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase," Nature, vol.
Tsukamoto, "Hepatic NPC1L1 overexpression ameliorates glucose metabolism in diabetic mice via suppression of gluconeogenesis," Metabolism, vol.
FGF21 promotes lipid catabolism, ketogenesis, and gluconeogenesis and improves insulin sensitivity and is an important target gene of PPAR[alpha] in the liver [34, 35].
Precipitants like muscle dystrophy [12], significant weight loss (sarcopenia) [11], and chronic liver disease [24] aggravate glycogen depletion and curtail gluconeogenesis with less substrates and poor liver function reserve.
But our liver keeps synthesizing more glucose (via gluconeogenesis) and pouring it into our blood.
Additionally, MAE improves hepatic insulin resistance through inhibiting PGC-1[alpha] and FOXO1 transcriptional activity to decrease gluconeogenesis as well as suppressing JNK phosphorylation to enhance insulin signalling transduction.
Four key enzymes regulate gluconeogenesis in humans: pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6 bisphosphatase, and glucose 6-phosphatase.
de Souza et al., "Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice," Journal of Physiology, vol.