Inconsistent results in the previous studies may be attributed to their varying dosages, route and duration of glucosamine administration, and the heterogeneity in the state of glucose condition in patients with diabetes, impaired glucose metabolism, and normoglycemic conditions.
In conclusion, oral glucosamine, when prescribed in routine doses in non-diabetic patients with OA, had no significant effect on blood glucose and insulin resistance.
Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance.
Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects.
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