Chronic hyperglycemia also induces myriad of biological reactions causing glucose toxicity
, which in turn causes [beta]-cell apoptosis [99-101].
Takahashi, "Glucose toxicity
in [beta]-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection," Diabetes, vol.
Diabetes, glucose toxicity
, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell.
Indeed, despite all the emerging data on postprandial glucose toxicity
It is time to reassess the question and ask "What test best identifies glucose toxicity
for the fetus?"
: The implications of hyperglycemia in the pathophysiology of diabetes mellitus.
"Since we are dealing with children and adolescents, whose blood sugars have not been high for long, this approach can rapidly eliminate glucose toxicity
, and we think their beta-cell function is then restored," Elizabeth Sellers, M.D., told this newspaper.
Most of the insulin resistance in patients with type 2 diabetes is linked to obesity (associated with defective leptin action), reduced physical activity, glucose toxicity
and high-fat diets.
EFFECT OF GLUCOSE ANALOGUES AND GLYCATION REVERSAL AGENTS ON GLUCOSE TOXICITY
IN A HALOPHILIC BACTERIUM ISOLATED FROM AN INLAND SALT SPRING.
Chronic hyperglycemia also termed glucose toxicity
has a strong impact of damage on beta-islet cell failure which origins from high glucose-inducing superfluous reactive oxygen species to aggravate oxidative stress in body tissue [9, 10].
Recent studies have suggested that short-term intensive insulin therapy, with continuous subcutaneous insulin infusion (CSII) potentially being the best current therapeutic option [2, 3], can rapidly relieve newly diagnosed T2DM patients of high glucose toxicity
, ameliorate the state of insulin resistance, and restore islet [beta]-cell function [4, 5].
* Glucose toxicity
. It is generally agreed that Insulin is the most effective treatment for patients who present with decompensated type 2 diabetes (4)--ie, with signifcant hyperglycemia and catabolic symptoms such as polydipsia, polyuria, and weight loss.