Elevated FFA has a stimulatory effect on glucose-6-phosphatase
, the terminal enzyme of glycogenolysis by allosteric mechanism which inturn increases hepatic glucose production resulting in hyperglycaemia (28).
Hypoglycemic effects of Coccinia indica: inhibition of key gluconeogenic enzyme, glucose-6-phosphatase
activity showed a significant increase in the liver tissue of fish exposed to lethal and sublethal concentration of deltamethrin (table 2).
Some tumors have either a relatively low overall glucose metabolic rate, relatively low levels of Glut-1 and other transporters, or high levels of glucose-6-phosphatase
, yielding an overall poor FDG uptake.
2010), prothrombin time (PT) and activated partial thromboplastin time (APTT) (Abdulrahaman and Dallatu, 2012), hepatic glucokinase (Chapman and Wong, 2002), hepatic glucose-6-phosphatase
(Bastaki, 2005), fructose-1,6-bisphosphatase (Riou et al.
Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase
activity in vitro by Svetol, a standardized decaffeinated green coffee extract.
Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase
gene transcription by insulin.
Key Presentations at the ADA Meeting: * Oral Presentations: * Using its proprietary second-generation antisense inhibitors, Isis and a large pharmaceutical collaborator successfully inhibited glucose-6-phosphatase
transport protein T1 (G6Pase T1) in ob/ob and db/db mouse models of diabetes.
The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase
, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver of diabetic rats were significantly reverted to near normal levels by the administration of tangeretin.
Confirmation of this began with a study concluding that the chlorogenic acids in coffee inhibit glucose-6-phosphatase
, in turn interfering with glucose synthesis and release within the body.
The activities of hexokinase, glucose-6-phosphatase
, fructose-1,6- bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase were measured.
25) It appears to accomplish this by inhibiting the pathway of glucose-6-phosphatase
, a glucose-regulating enzyme, which in turn results in a reduction of sugar levels in the blood.