glucose-6-phosphatase


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Related to glucose-6-phosphatase: glucose-6-phosphate dehydrogenase

glucose-6-phosphatase

[′glü‚kōs ¦siks ′fäs·fə‚tās]
(biochemistry)
An enzyme found in liver which catalyzes the hydrolysis of glucose-6-phosphate to free glucose and inorganic phosphate.
References in periodicals archive ?
Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion.
Enes P, Panserat S, Kaushik S, Oliva-Teles A (2008) Hepatic glucokinase and glucose-6-phosphatase responses to dietary glucose and starch in gilthead sea bream (Sparus aurata) juveniles reared at two temperatures.
Genetic basis of glycogen storage disease type 1a: Prevalent mutations at the glucose-6-phosphatase locus.
Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase.
As far as the mechanism of action is concerned, we may speculate that the anti-diabetic activity of the extract may increase the glucose uptake, (33) or may be partly mediated through suppression of the gluconeogenic enzymes, glucose-6-phosphatase.
Glycogen synthesis is produced in numerous tissues, especially in the liver, kidneys, and muscle; and mainly deposited in the liver and muscle, but the latter lacks glucose-6-phosphatase, an enzyme that acts in the light of the endoplasmic reticulum and turns glucose-6-phosphatase into free glucose (2,3) and, hence, insufficient amounts of glucose is liberated onto the systemic circulation given that the function of muscular glycogen is to serve as a source of energy for its own activity.
The activities of hexokinase and pyruvate kinase were reduced while the activities of glucose-6-phosphatase and fructosel, 6-bisphosphatase were increased in rats fed high fructose.
A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3).
says that SRC-2 works with an orphan nuclear receptor ROR alpha to affect the activity of the sugar-converting enzyme, glucose-6-phosphatase in the liver.
Since glucose-6-phosphatase is very sensitive to the action of hepato toxic chemicals, decreases in its activity are regarded as useful biochemical index of early toxic liver damage which ipso facto can also be used as a biomarker of hydrocarbon poisoning.
Keywords: Glucose-6-phosphatase, nuclear envelope, microsomes, phlorizin.

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