Transaminase

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transaminase

[¦tranz′am·ə‚nās]
(biochemistry)
One of a group of enzymes that catalyze the transfer of the amino group of an amino acid to a keto acid to form another amino acid. Also known as aminotransferase.

Transaminase

 

(also aminotransferase and aminopherase), an enzyme of the transferase group that catalyzes the transfer of an amino group (—NH2) from an α-amino acid to an α-keto acid. Transaminases are found in most animal and plant tissues and play an important part in nitrogen metabolism. The role of transaminase in the transamination process was discovered by the Soviet biochemists A. E. Braunshtein and M. G. Kritsman in 1937. The coenzyme in transaminase reactions is pyridoxal phosphate, the aldehyde group of which serves as intermediate acceptor of the amino group. The resulting pyridoxamine phosphate transfers the amino group to the ketone group of the acid undergoing amination. The reaction is reversible.

A. A. BOLDYREV

References in periodicals archive ?
Glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), total cholesterol, HDL cholesterol and LDL cholesterol in blood were analyzed according to AOAC (1995).
The activities of glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) in the serum were measured according to the colorimetric method using a GOT-GPT assay kit (GOT-GPT assay kit, Asan Pharmaceutical, Hwaseong-si, Korea).
The blood samples that were collected without anticoagulant were centrifuged at 1,000xg for 20 min at 4[degrees]C and the serum were partitioned into aliquots and stored at -20[degrees]C until analyzed for albumin, glucose, blood urea nitrogen (BUN), calcium, creatinine, glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), and globulin with a serum analyzer (Hitachi Chemistry Analyzer 7180, Japan).
The concentrations of total cholesterol (TC) and the activities of glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) in the serum were measured according to the colorimetric method using a cholesterol diagnostic-kit (Cholesterol E kit, Asan Pharmaceutical) and a GOT-GPT assay kit (GOT-GPT assay kit, Asan Pharmaceutical), respectively.

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