glutaminase


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glutaminase

[glü′tam·ə‚nās]
(biochemistry)
The enzyme which catalyzes the conversion of glutamine to glutamic acid and ammonia.
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Biochemical Characterization of a Novel L-Asparaginase with low Glutaminase activity from Rhizomucor miehei and its application in food safety and leukemia treatment.
Purification, Characterization and Anticancer Activity of L-asparaginase Produced by Marine Aspergillus terreus
Glial cells throughout the body, especially in muscles that are starved of glucose (hypoglycaemia) will die, spilling out their carefully guarded reserves of glutamine and the enzyme glutaminase --a deadly duo that becomes glutamate and joins up with calcium, its excitable partner.
MSG Excites Us, But How About Glutamine and Glutamate?
Karsten Suhre, analyzed the metabolic processes of cancer cells to show that the quinine-based malaria drug Chloroquine could boost the effectiveness of glutaminase inhibiting drugs, which are currently being developed by global pharmaceutical companies.
WCM-Q Researchers: Malaria Drug Could Make Cancer Treatments More Effective
Role of phosphate-activated glutaminase in the pathogenesis of hepatic encephalopathy.
Ammonium consequences in athletes' central fatigue and its possible neuroprotection effect thanks to physical activity/Consecuencias del amonio en la fatiga central en atletas, posible efecto neuroprotector del ejercicio/Consequencias do amonio na fadiga central em atletas, possivel efeito neuroprotetor do exercicio
Majority of children with type 1 diabetes produce and deposit anti-tissue trans glutaminase antibodies in the small intestine.
HISTOLOGICAL OUTCOME OF DUODENAL BIOPSIES IN PATIENTS WITH CLINICALLY SUSPECTED CELIAC DISEASE - A STUDY OF 100 CASES
-- Combination treatment with the first-in-class glutaminase inhibitor CB-839 and nivolumab is well tolerated and shows clinical activity in patients with three types of cancer, including advanced melanoma, according to initial results of a phase 1/2 study
Novel agent shows potential benefits for refractory disease
Glutamine is transferred back to neurons to be used as a substrate for the enzyme glutaminase (GLS), which removes an amide group from glutamine to produce glutamate and ammonia [61] (Figure 2).
Astrocytes and the Warning Signs of Intracerebral Hemorrhagic Stroke
led to the discovery that the consumption rate of glucose, glutamine, and fatty acids and the enzymatic activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, citrate synthase, oxoglutarate dehydrogenase, and glutaminase differ in resting and elicited (inflammatory) macrophages [54].
Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases
Transcription factors such as c-myc upmodulate the expression of the ASCT2 transporter and regulate the expression of other glutamine transporters and enzymes involved in the conversion of glutamine to glutamate (GLU) such as glutaminase (GLS1) [20].
Metabolic Footprints and Molecular Subtypes in Breast Cancer
Screening and kinetics of glutaminase and glutamate decarboxylase producing lactic acid bacteria from fermented Thai foods.
Screening of lactic acid bacteria with immune modulating property, and the production of lactic acid bacteria mediated fermented soymilk
[23] Gln is converted to Glu by the glutaminase in presynaptic neurons.
Prefrontal Cortex GABA in Schizophrenia and Abnormal Glutamate Concentration: An in Vivo 1H-MRS Study
Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: Phosphate-activated glutaminase and glutamic acid decarboxylase.
OPTIMIZATION OF ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY (UPLC) WITH FLUORESCENCE DETECTOR (FLD) METHOD FOR THE QUANTITATIVE DETERMINATION OF SELECTED NEUROTRANSMITTERS IN RAT BRAIN

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