glutaminase


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glutaminase

[glü′tam·ə‚nās]
(biochemistry)
The enzyme which catalyzes the conversion of glutamine to glutamic acid and ammonia.
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Biochemical Characterization of a Novel L-Asparaginase with low Glutaminase activity from Rhizomucor miehei and its application in food safety and leukemia treatment.
Glial cells throughout the body, especially in muscles that are starved of glucose (hypoglycaemia) will die, spilling out their carefully guarded reserves of glutamine and the enzyme glutaminase --a deadly duo that becomes glutamate and joins up with calcium, its excitable partner.
Karsten Suhre, analyzed the metabolic processes of cancer cells to show that the quinine-based malaria drug Chloroquine could boost the effectiveness of glutaminase inhibiting drugs, which are currently being developed by global pharmaceutical companies.
Majority of children with type 1 diabetes produce and deposit anti-tissue trans glutaminase antibodies in the small intestine.
-- Combination treatment with the first-in-class glutaminase inhibitor CB-839 and nivolumab is well tolerated and shows clinical activity in patients with three types of cancer, including advanced melanoma, according to initial results of a phase 1/2 study
Glutamine is transferred back to neurons to be used as a substrate for the enzyme glutaminase (GLS), which removes an amide group from glutamine to produce glutamate and ammonia [61] (Figure 2).
led to the discovery that the consumption rate of glucose, glutamine, and fatty acids and the enzymatic activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, citrate synthase, oxoglutarate dehydrogenase, and glutaminase differ in resting and elicited (inflammatory) macrophages [54].
Transcription factors such as c-myc upmodulate the expression of the ASCT2 transporter and regulate the expression of other glutamine transporters and enzymes involved in the conversion of glutamine to glutamate (GLU) such as glutaminase (GLS1) [20].
Screening and kinetics of glutaminase and glutamate decarboxylase producing lactic acid bacteria from fermented Thai foods.
[23] Gln is converted to Glu by the glutaminase in presynaptic neurons.
Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: Phosphate-activated glutaminase and glutamic acid decarboxylase.

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