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see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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γ-glutamyl cysteinyl glycine, a tripep-tide formed from radicals of three amino acids—glutamic acid, cysteine, and glycine. A peculiarity of the structure of glutathione is the peptide bond between cysteine and glutamic acid, in which the γ-carboxyl of the glutamic acid participates. Glutathione is present in all living organisms and is very important for oxidation-reduction reactions in connection with the capacity of the sulfhydryl group (SH—) of cysteine to undergo the reversible reaction

Glutathione can act as a coenzyme in the action of cathepsins, papain, and other proteolytic enzymes. The function of glutathione in metabolism apparently also includes the protection of the SH group of cytoplasm proteins against oxidation.


C10H17O6N3S A widely distributed tripeptide that is important in plant and animal tissue oxidation reactions.
References in periodicals archive ?
In the porcine GSTpi, glutathione sulfonate makes 15 polar contact and four water mediated contacts at the G-site (Dirr et al.
Beelman said that future research may look at any role that ergothioneine and glutathione have in decreasing the likelihood of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.
Intravenous glutathione for skin lightening: Inadequate safety data.
Tory Hagen, lead researcher of the study conducted at Oregon State University, commented, "We've known for some time of the importance of glutathione as a strong antioxidant.
Antioxidant enzymes superoxide dismutase, glutathione peroxidase, catalase, and antioxidant substances are among the antioxidative materials of the antioxidative system of the body that has an inherent place within this system (5).
Taylor hyperpigmentation scale, glutathione, anaphylaxis, skin tone.
The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and metaanalysis.
A particular concentration of glutathione is necessary for the normal physiological function of cell.
Theodore Hersh, a renowned professor of the Emory University School of Medicine, who has over 20 patents under his name in the development of glutathione and selenium products.
In order to create models of the glutathionylated Na,K-ATPase, a corresponding model structure of glutathione was manually inserted into the cavity with unresolved electronic density (negative density and blob) using COOT.

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