glutathione


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glutathione:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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.

Glutathione

 

γ-glutamyl cysteinyl glycine, a tripep-tide formed from radicals of three amino acids—glutamic acid, cysteine, and glycine. A peculiarity of the structure of glutathione is the peptide bond between cysteine and glutamic acid, in which the γ-carboxyl of the glutamic acid participates. Glutathione is present in all living organisms and is very important for oxidation-reduction reactions in connection with the capacity of the sulfhydryl group (SH—) of cysteine to undergo the reversible reaction

Glutathione can act as a coenzyme in the action of cathepsins, papain, and other proteolytic enzymes. The function of glutathione in metabolism apparently also includes the protection of the SH group of cytoplasm proteins against oxidation.

glutathione

[¦glüd·ə′thī‚ōn]
(biochemistry)
C10H17O6N3S A widely distributed tripeptide that is important in plant and animal tissue oxidation reactions.
References in periodicals archive ?
In group A 16 patients were given intravenous glutathione and vitamin C.
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
Max International has solved this conundrum with its proprietary and patented technology RiboCeine, which has shown to be 300% more effective than the traditional N-acetyl-cysteine formula in raising glutathione levels in the liver.
He, however, added that there had been reports of people suffering from severe skin disorders after taking intravenous glutathione for one reason or the other.
With glutathione affecting the production of melanin, the FDA also said that there were "theoretical concerns" on the possible risk of skin cancer.
The mean total glutathione levels in liver tissue homogenate of group I was 4.29 +- 0.42 umol/L while in group II it was 1.92 +- 0.28 umol/L.
In the epidermis, compared to the dermis, higher concentrations of catalase, glutathione peroxidase, glutathione reductase and ascorbic acid have been demonstrated.
Because sulforaphane changed the glutamate imbalance in the rat brains and affected how messages were transmitted between the rat brain cells, the researchers wanted to test whether sulforaphane could change glutathione levels in healthy people's brains and see if this could eventually be a strategy for people with mental disorders.
Rob Keller introduced his patented original glutathione formula (OGF) with substances including l-glutamine, n-acetyl cysteine and alpha lipoic acid.
Glutathione, when clubbed along with Vitamin C, increases glutathione's intracellular stores in the body.
Moderately affected patients have hemolytic anemia and metabolic acidosis, resulting in low levels of glutathione in erythrocytes.

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