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Related to glutathione peroxidase: Glutathione reductase


see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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γ-glutamyl cysteinyl glycine, a tripep-tide formed from radicals of three amino acids—glutamic acid, cysteine, and glycine. A peculiarity of the structure of glutathione is the peptide bond between cysteine and glutamic acid, in which the γ-carboxyl of the glutamic acid participates. Glutathione is present in all living organisms and is very important for oxidation-reduction reactions in connection with the capacity of the sulfhydryl group (SH—) of cysteine to undergo the reversible reaction

Glutathione can act as a coenzyme in the action of cathepsins, papain, and other proteolytic enzymes. The function of glutathione in metabolism apparently also includes the protection of the SH group of cytoplasm proteins against oxidation.


C10H17O6N3S A widely distributed tripeptide that is important in plant and animal tissue oxidation reactions.
References in periodicals archive ?
New transcripts for Botryllus Cu/Zn superoxide dismutase (SOD), [gamma]-glutamyl-cysteine ligase modulatory subunit (GCLM), glutathione synthase (GS), and two glutathione peroxidases (GPx3 and GPx5) are described, and their location in hemocytes is demonstrated through in situ hybridization (ISH).
Glutathione peroxidase activity in HL of ark shells exposed to 32[degrees]C showed a biphasic change with an increase at 12 h followed by a significant decrease (P < 0.
Oxidative status, in vitro iron-induced lipid oxidation and superoxide dismutase, catalase and glutathione peroxidase activities in rhea meat.
001 ** SD, standard deviation; CAT, catalase; SOD, superoxide dismutase, GPx, glutathione peroxidase.
Glutathione peroxidase activity was measured using the kit of Randox Glutathione Peroxidase (Ransel), supplied by Randox Laboratories (United Kingdom), according to the manufacturer's protocol.
Bartley, "The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver," The Biochemical Journal, vol.
87) And in humans, supplementing with 200 micrograms per day of selenium significantly increased glutathione peroxidase activity by 11%.
The enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) are part of the first line of enzymatic defence (21), using catalytic co-factors, microelements, such as selenium, iron, copper, zinc for the ROS metabolisation (22).
The antioxidant defense system of the body include enzymes like super oxide dismutase (SOD), Glutathione peroxidase (GPx), Glutathione reductase (GR) and low molecular weight free radical scavengers like glutathione, ascorbate and alfa tocopherol.
Taurine increases the activities of antioxidant enzymes like superoxide dismutase, glutathione peroxidase and catalase.
It is a part of the enzyme glutathione peroxidase (GSH-Px) as selenocysteine, and it is readily ionizable at physiological pH.

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