glycan


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glycan

[′glī‚kan]
(biochemistry)
References in periodicals archive ?
As part of a physicochemical similarity exercise (not comparability), the authors present data on glycan microheterogeneity using hydrophilic interaction ultra-performance-liquid-chromatography (HILIC-UPLC) on three batches of Enbrel and one batch of Infinitam (Figure 3 panel b of Miranda-Hernandez et al.).
"The ability to identify the glycan fingerprint on HIV's glycoprotein will help us develop a vaccine that matches what is found on the virus," James Paulson, a biochemist at the institute and lead author of a study describing the technique, said in a (https://www.eurekalert.org/pub_releases/2017-03/sri-trd032817.php) statement released Tuesday. 
High-resolution native electrospray ionization mass spectrometry on a modified Exactive Orbitrap mass analyser demonstrated qualitatively and semi-quantitatively 59 proteoforms in the natural protein, induced by 45 different glycan structures and a number of phosphorylation sites.
On the other hand, the complexity of the glycan structures, the multiple substitutions at glycosylation sites, and the structural diversity associated with the protein backbone posed a giant challenge for the glycoprotein analysis.
As biopharmaceutical glycosylation is becoming more complex, the glycan database will be essential because it will enable automated and user-independent analysis.'
The researchers initially thought that the glycans may be involved in the interactions with innate immune cells known as neutrophils.
Migration speed differences can often be detected for different glycan isoforms carried by the same protein.
The team has now engineered a harmless portion of the toxin to enhance its specificity for the cancer glycan and used this to detect it in blood samples from women with ovarian cancer.
Mounting evidence suggests glycans play an important role in human development, health and disease, and should be taken into account when new therapeutics are designed and tested, the company added.
This acquisition will expand Agilent's portfolio of biopharma consumables in the fast-growing glycan market.
Palo Alto, CA, July 13, 2018 --(PR.com)-- PREMIER Biosoft today announced that Jonathan Bones, Ph.D., has joined its Scientific Advisory Board (SAB) to assist the company in its efforts to offer solutions in glycan analysis for Bio-pharmaceuticals.
A statement issued by the Operations Command said that 37 improvised explosive devices (IEDs) and 65 improvised in the form of a 20-liter Glycan of C4 were detonated in the area between Al-Salam Interchange and Al-Falafat train station and al-Nassaf areas.