glycan

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glycan

[′glī‚kan]

(biochemistry)

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As part of a physicochemical similarity exercise (not comparability), the authors present data on glycan microheterogeneity using hydrophilic interaction ultra-performance-liquid-chromatography (HILIC-UPLC) on three batches of Enbrel and one batch of Infinitam (Figure 3 panel b of Miranda-Hernandez et al.).

Comment on "New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept"

"The ability to identify the glycan fingerprint on HIV's glycoprotein will help us develop a vaccine that matches what is found on the virus," James Paulson, a biochemist at the institute and lead author of a study describing the technique, said in a (https://www.eurekalert.org/pub_releases/2017-03/sri-trd032817.php) statement released Tuesday. 

New Technique To 'Fingerprint' HIV Could Help Create Effective Vaccine

High-resolution native electrospray ionization mass spectrometry on a modified Exactive Orbitrap mass analyser demonstrated qualitatively and semi-quantitatively 59 proteoforms in the natural protein, induced by 45 different glycan structures and a number of phosphorylation sites.

The complexity of glycoprotein-derived glycans

On the other hand, the complexity of the glycan structures, the multiple substitutions at glycosylation sites, and the structural diversity associated with the protein backbone posed a giant challenge for the glycoprotein analysis.

Creative Biolabs Announces Custom Glycoprotein Synthesis and Glycoprotein Detections Services

As biopharmaceutical glycosylation is becoming more complex, the glycan database will be essential because it will enable automated and user-independent analysis.'

Agilent Presents Thought Leader Award to Professor Hyun Joo An

The researchers initially thought that the glycans may be involved in the interactions with innate immune cells known as neutrophils.

Sperm's 'Secret Handshake' To Uterus Key To Suppressing Female's Immune Response

Migration speed differences can often be detected for different glycan isoforms carried by the same protein.

Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases

The team has now engineered a harmless portion of the toxin to enhance its specificity for the cancer glycan and used this to detect it in blood samples from women with ovarian cancer.

New blood test detects early stage ovarian cancer

Mounting evidence suggests glycans play an important role in human development, health and disease, and should be taken into account when new therapeutics are designed and tested, the company added.

BloodCenter of Wisconsin wins USD5m NIH glycosciences grant

This acquisition will expand Agilent's portfolio of biopharma consumables in the fast-growing glycan market.

Agilent Technologies Closes Acquisition of ProZyme, Expanding Biopharma Consumables Portfolio

Palo Alto, CA, July 13, 2018 --(PR.com)-- PREMIER Biosoft today announced that Jonathan Bones, Ph.D., has joined its Scientific Advisory Board (SAB) to assist the company in its efforts to offer solutions in glycan analysis for Bio-pharmaceuticals.

Dr. Jonathan Bones Joins PREMIER Biosoft Scientific Advisory Board to Further the Development of Glycomics Software Solutions for Biopharmaceutical Research & Development

A statement issued by the Operations Command said that 37 improvised explosive devices (IEDs) and 65 improvised in the form of a 20-liter Glycan of C4 were detonated in the area between Al-Salam Interchange and Al-Falafat train station and al-Nassaf areas.

Anbar Command detonates/152/explosive devices

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