The glycolytic pathway
and its relationship to the endoplasmic reticulum are easily understood by referring to the pdf file available at the website noted in reference 3.
In addition, we found that glucose-6-phosphate and glucose-1-phosphatein glycolytic pathway
were increased significantly in DA group, as well as the TAC products such as oxalate and 2-hydroxybutanoic acid.
9] In the normal glycolytic pathway
, FDG behaves similarly to D-glucose.
A parsimonious explanation of these findings is that after fluoride is mixed with blood it rapidly blocks enolase (within <5 min), and that enzymes upstream of enolase in the glycolytic pathway
Briefly, lactic acid, or lactate, is one of two possible products produced by alternative reactions in the glycolytic pathway
When oxygenation reaches low critical levels, conservative strategies favor reversible inhibition of the glycolytic pathway
, coupled with additional substrate-level phosphorylations (Hochachka & Somero 2002).
The glucose so produced or the glucose absorbed from diet undergoes a series of reactions through anaerobic glycolytic pathway
in the tissues to produce pyruvic acid and then lactic acid or the pyruvic acid undergoes oxidative decarboxylation to form acetyl Co-A which is channelised into aerobic Kreb's cycle, which in its cycle generates reduced nucleotides (NADH and FAD) for the ultimate generation of biological currency, ATP through electron transport system.
I assumed that the inhibition of aerobic oxidation was compensated by the increased intensity of the anaerobic glycolytic pathway
of energy supply for maintenance.
The up-regulation of the glycolytic pathway
may be beneficial for cell survival, and if Ni(II) exposure is prolonged, it may select cells that maintain a high glycolytic rate and thereby acquire a phenotype similar to cancer cells, as described by Warburg (1956).
With hexose as a generic substrate, flow of carbon can be traced through the glycolytic pathway
(found in cytosol and plastids) to the tricarboxylic acid (TCA) cycle in the matrix solution of mitochondria.
Agios scientists discovered novel compounds that effectively increase activity of a cancer-associated isoform of pyruvate kinase (PKM2) in the glycolytic pathway
, which is a conserved metabolic pathway that processes sugar to fuel cell growth.