The comparative pathology of the
glycosidase inhibitors swainsonine, castanospermine, and calystegines A3, B2, and C1 in mice.
Alpha galactosidase and alpha
glycosidase enzyme activity were correlated both with neutrophils and lymphocytes.
Iminosugars are small molecule therapeutics that target host
glycosidase enzymes leading to reduced virus infectivity in multiple viruses such as dengue, Zika, SARS, and influenza.
Moreover, the expression of
glycosidase genes specific for the hydrolysis of the transported saccharides was also detected, indicating the functional use of these sugars, including alpha- and beta-glycosidases (altogether denoted as glycosylase genes) (Figure 5; Supplementary Table 1).
Therefore, Chinese traditional medicine containing glycosides can inhibit enzyme activity and protect glycosides by frying, cooking, and other methods, which can effectively control the
glycosidase solution [23].
Loessner, "Reporter bacteriophage A511:celB transduces a hyperthermostable
glycosidase from Pyrococcus furiosus for rapid and simple detection of viable Listeria cells," Bacteriophage, vol.
This strong inhibition effects of compounds (14-16) are in accordance with literature data, concerning fivemembered iminocyclitol derivatives as potent
glycosidase inhibitors [38].
The oxidized products can then be processed directly by the TDG (thymine DNA
glycosidase) generating a site that can be repaired by the BER machinery [15] or deaminated by AID deaminases (activation-induced cytidine deaminase), generating 5-hydroxymethyluracil (5hmU), which can also be excised by the TDG [16].
At present, the improvement of insulin resistance agent in clinic mainly include five categories: metformin, sulfonylureas, thiazolidinediones, megliginides and alpha
glycosidase inhibitor, which have a number of potential side effects.
As a result, 10 components of Radix Isatidis with glycosyls were deglycosylated according to the rule of
glycosidase hydrolysis reaction.
Wine LAB possess
glycosidase enzymes capable of liberating varietal aroma precursors into the media.
(1991, 1997) reported the presence of alkaloidal
glycosidase inhibitors in the species O.