glycosphingolipid


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glycosphingolipid

[¦glī·kō‚sfiŋ·gō′lip·id]
(biochemistry)
A glycoside of ceramide that is the most abundant and structurally diverse type of glycolipid in animals.
References in periodicals archive ?
In SRT, small molecule drugs are ingested orally, which inhibit the first step in glycosphingolipid biosynthesis, aiming to reduce the rate of glycosphingolipid biosynthesis resulting in reduction of the catabolic effects.
4], was utilized by many researchers in the synthesis of complex glycosides such as Avermectin, (18) Trimeric Lex, (19) Agelagalastatin, (20) [beta]-Mannoside, (21) and glycosphingolipid KRN7000 (Fig.
CA 19-9 is a glycosphingolipid of the Lewis group that is well known as a tumor-associated antigen.
The glycosphingolipid globotriaosylceramide was shown to bind CD1d and inhibit the activation of a subset of CD1d-restricted T cells, the invariant Natural Killer T (iNKT) cells [70].
pap-2-encoded fimbriae adhere to the P blood group-related glycosphingolipid stage-specific embryonic antigen 4 in the human kidney.
Fabry disease (FD) is a disease characterized by the pathological accumulation of glycosphingolipid Gb3 in some cells; it progresses with a lack of lysosomal alpha-galactosidase and is inherited in an X-linked recessive manner (1).
The NMR data (Table-4) of 4 and its comparison with those of the data of compounds 1-3 revealed a glycosphingolipid nature of 4.
Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells.
The offender, the researchers say, is a fat-and-sugar molecule called glycosphingolipid, or GSL, which resides in the membranes of all cells, and is mostly known for regulating cell growth.
Cardiac and vascular hypertrophy in Fabry disease: evidence for a new mechanism independent of blood pressure and glycosphingolipid deposition.
8 In 1967, Brady et al found that the disease is caused by deficiency of an enzyme galactosidase, required for glycosphingolipid metabolism.