Newer experiences demonstrate that higher levels of MGO, the MGO derived AGEs (MGO-AGE) and hydroimidazolone-1 (MGO-H1), along with dysfunctioning framework of
glyoxalase are connected to a few age-related medical issues including certain cardiovascular problems, diabetes, disorders of central nervous system and cancer.
Exogenous pro line and glycine betaine mediated upregulation of antioxidant defense and
glyoxalase systems provides better protection against salt-induced oxidative stress in two rice (Oryza sativa L.) varieties.
Exogenous proline and glycine betaine mediated upregulation of antioxidant defense and
glyoxalase systems provides better protection against salt-induced oxidative stress in two rice (Oryza sativa L.) varieties.
Piceatannol, a natural trans-stilbene compound, inhibits human
glyoxalase I.
In addition, Ni can activate an isoform of
glyoxalase I that catalyze an important step in the degradation of methylglyoxal (MG), a compound naturally produced by cellular metabolism that may be lethal to cell functions.
Exogenous nitric oxide alleviates high temperature induced oxidative stress in wheat ( Triticum aestivum L.) seedlings by modulating the antioxidant defense and
glyoxalase system.
(31) demonstrated that oleanolic acid (0.1 and 0.2%) and ursolic acid (0.1 and 0.2%) markedly suppressed renal aldose reductase activity and enhanced
glyoxalase I activity, which contributed to decrease renal advanced glycation end products formation and improvedd renal functions.
Enzyme D-isomer specific 2-hydro xyacid dehydrogenase, whose expression levels was altered only in the Bolivia strain (Table 3, spot 3), was one of the proteins identified in the present work This enzyme is responsible to catalyze the NAD-dependent oxidation of R-lactate to pyruvate and is part of the detoxification pathway of methylglyoxal (dependent of
glyoxalase I,
glyoxalase II and low molecular mass thiols) in trypanosomatids, and data from Trypanosoma conorhini and Crithidia fasciculata showed activation in the presence of cysteine.
Creighton, "Inhibition by active site directed covalent modification of human
glyoxalase I," Bioorganic & Medicinal Chemistry, vol.
gloA encodes
glyoxalase I, an (R)-S-lactoylglutathione methylglyoxal lyase (isomerizing) activated by Zn(II) or Ni(II) ions, and is 411 bp (136 amino acids) in length.
Zhou, "Methylglyoxal as a novel signal molecule induces the salt tolerance of wheat by regulating the
glyoxalase system, the antioxidant system, and osmolytes," Protoplasma, vol.
reduced activity of the enzyme
glyoxalase (which is deficient in