primordial germ cell

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primordial germ cell

[prī¦mȯrd·ē·əl ′jərm ‚sel]
(embryology)
Embryonic cell giving rise to a germ cell from which a gamete (egg or sperm) develops.
References in periodicals archive ?
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma.
Gonocyte numbers are, however reported to be increased in mice testis towards the end of gestation suggesting an inhibitory role for androgen.
DEHP/DBP exposure also induces germ cell effects in the fetal rat testis, namely, induction of multinucleated gonocytes (MNGs) (Ferrara et al.
CIS have both stemand germ-cell properties and originate from undifferentiated gonocytes because of poor function of Sertoli and/or Leydig cells during testis development.
Stereologic analyses to determine cell numbers used AMH-immunostained slides for Sertoli cell and gonocyte counts and P450scc-immunostained slides for Leydig cell counts.
A possible driver of neoplastic transformation of maturation-arrested gonocytes is the failure of these cells to downregulate expression of OCT3/4, an antiapoptotic oncofetal protein, a process that normally occurs when gonocytes relocate from the center of the seminiferous tubule to the spermatogonial niche.
According to recent knowledge testicular physiology is marked by the transformation of neonatal gonocytes in the period from 3 to 12 months after birth.
According to previous studies, co-expression of UCHL1 and promyelocyticleukaemia zinc finger protein PLZF in gonocytes and spermatogonia induced self-renewal and prevented differentiation (20).
Once they arrive in the genital ridge, the PGCs are enclosed by somatic Sertoli cells and become gonocytes (2).
1998 Different fate of primordial germ cells and gonocytes following transplantation.
Migration of gonocytes into the mammalian gonad and their differentiation.
In the mouse, spermatogenesis begins in the fetal period, when the seminiferous tubules contain mature Sertoli cells and gonocytes.