The researchers therefore wanted to test which other molecular pathways might be responsible for the reduction in gonocyte
number that they observed.
Primary germ cells (gonocytes
) were located in the center of the cords.
In the human fetal testis, in culture (first trimester) the effect on GC number resulted from a reduction in the [TFAP2C.sup.+] gonocyte
population, whereas in xenografts (second trimester) the reduction in germ cell number appeared to involve [TFAP2C.sup.+] and more differentiated prespermatogonia ([MAGEA4.sup.+]).
Carcinoma-in-situ of the testis: possible origin from gonocytes
and precursor of all types of germ cell tumours except spermatocytoma.
DEHP/DBP exposure also induces germ cell effects in the fetal rat testis, namely, induction of multinucleated gonocytes
(MNGs) (Ferrara et al.
CIS have both stemand germ-cell properties and originate from undifferentiated gonocytes
because of poor function of Sertoli and/or Leydig cells during testis development.
Determination of the Sertoli cell and gonocyte
The cells within region of GE were not properly differentiated and were distributed virgoursly in both groups comprising of both Sertoli cells and Gonocytes
. The sertoli cells were somewhat polygonal in shape and their cytoplasm was homogenous.
Additionally, immature germ cells show morphologic features of primordial germ cells or gonocytes
and, as such, have large nuclei, prominent nucleoli, and pale to lightly eosinophilic cytoplasm (Figure 1, B).
The primitive SG-A cells contain both SSCs and gonocytes
, while SG-A cells are mostly differentiating SG with a small proportion of stem cells.
During male embryogenesis, primordial germ cells (PGCs) derived from the epiblast relocate in the genital ridges and experience differentiation into gonocytes