Carcinoma-in-situ of the testis: possible origin from gonocytes
and precursor of all types of germ cell tumours except spermatocytoma.
numbers are, however reported to be increased in mice testis towards the end of gestation suggesting an inhibitory role for androgen.
DEHP/DBP exposure also induces germ cell effects in the fetal rat testis, namely, induction of multinucleated gonocytes
(MNGs) (Ferrara et al.
CIS have both stemand germ-cell properties and originate from undifferentiated gonocytes
because of poor function of Sertoli and/or Leydig cells during testis development.
Stereologic analyses to determine cell numbers used AMH-immunostained slides for Sertoli cell and gonocyte
counts and P450scc-immunostained slides for Leydig cell counts.
A possible driver of neoplastic transformation of maturation-arrested gonocytes
is the failure of these cells to downregulate expression of OCT3/4, an antiapoptotic oncofetal protein, a process that normally occurs when gonocytes
relocate from the center of the seminiferous tubule to the spermatogonial niche.
According to recent knowledge testicular physiology is marked by the transformation of neonatal gonocytes
in the period from 3 to 12 months after birth.
According to previous studies, co-expression of UCHL1 and promyelocyticleukaemia zinc finger protein PLZF in gonocytes
and spermatogonia induced self-renewal and prevented differentiation (20).
Once they arrive in the genital ridge, the PGCs are enclosed by somatic Sertoli cells and become gonocytes
1998 Different fate of primordial germ cells and gonocytes
Migration of gonocytes
into the mammalian gonad and their differentiation.
In the mouse, spermatogenesis begins in the fetal period, when the seminiferous tubules contain mature Sertoli cells and gonocytes