Achaogen has other programs in early and late preclinical stages of development focused on other MDR
gram-negative infections and additional disease areas.
The company will leverage the DEX platform to support the discovery and development of novel chemical scaffolds targeting
Gram-negative pathogens.
Increasing incidence of
Gram-Negative organisms in bacterial agents isolated from diabetic foot ulcers.
Now, a team of researchers may have figured out a way of getting antibiotics that normally don't work on
Gram-negative bacteria inside those cells.
The diabetic group showed no significant difference in frequency of bacterial growth compared to the control group, but yielded more
gram-negative bacterial cultures.
A
gram-negative cell's thin wall crumbles in the alcohol wash and releases the dye.
On physical exam, both patients had maceration of the toe-webs with a hyperkeratotic rim, a finding noted in other reports of
gram-negative toe-web infections.
Results from the current study, conducted at six sites across the United States, are supported by prior regional studies indicating a shift in bacterial epidemiology from Group B strep toward
gram-negative pathogens in young infants.
A snapshot of the global therapeutic scenario for
Gram-Negative Bacterial Infections.
The antibiotic pipeline against multidrug-resistant
Gram-negative problem pathogens is a major unmet need in contemporary medicine; as such, our new antimicrobial agent holds immediate promise" says cosenior author Wadih Arap, professor in the Department of Genitourinary Medical Oncology.
Gram-negative bacteria have a more complex cell wall than gram-positive bacteria.
To begin with, there are fewer antibiotic options for treating infections caused by
Gram-negative bacteria than for those caused by Gram-positive bacteria," said Dr.
