sarcoma

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Related to granulocytic sarcoma: chloroma

sarcoma

(särkō`mə), highly malignant tumor arising in connective- and muscle-cell tissue. It is the result of oncogenes (the cancer causing genes of some viruses) and proto-oncogenes (cancer causing genes in human cells). It may affect bone, cartilage, blood vessels, lymph nodes, and skin. See cancercancer,
in medicine, common term for neoplasms, or tumors, that are malignant. Like benign tumors, malignant tumors do not respond to body mechanisms that limit cell growth.
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; neoplasmneoplasm
or tumor,
tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to cell death. Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair
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.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Sarcoma

 

a malignant tumor that consists of connective tissue. Mesenchymomas, which are sarcomas made up of embryonic connective tissue (mesenchyma), are distinguished from sarcomas made up of mature tissues of mesenchymal origin, for example, bone sarcomas (osteosarcomas), cartilaginous sarcomas (chondrosarcomas), vascular sarcomas (angiosarcomas), hematopoietic sarcomas (reticulosarcomas), muscular sarcomas (leiomyosarcomas, rhabdosarcomas), and sarcomas of skeletal nerve tissue (gliosarcomas).

Sarcomas constitute about 10 percent of all malignant tumors; they occur relatively more often in some African and Asian countries. The most common sarcomas are bone tumors and tumors of soft tissues, including muscular, vascular, and nerve tissues. Sarcomas of the hematopoietic organs occur less frequently. Histomorphologically, there are round-cell, polymorphocellular (sometimes giant-cell), and spindle-cell sarcomas, all of which differ in the shape and size of the cells, and fibrosarcomas, in which fibrous elements predominate over cellular elements.

All malignant tumors are characterized by growing into and destroying surrounding tissues; this property is especially pronounced in sarcomas. The early stages of cancers differ from the early stages of sarcomas; cancers metastasize to the nearest lymph nodes, while sarcomas usually spread by way of the bloodstream and frequently metastasize to remote organs.

The principles and methods of diagnosis, preventive measures, and treatment of sarcomas are the same as those used for other malignant tumors.

REFERENCE

Klinicheskaia onkologiia. Edited by N. N. Blokhin and B. E. Peterson, vols. 1–2. Moscow, 1971.

L. M. SHABAD

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

sarcoma

[sär′kō·mə]
(medicine)
A malignant tumor arising in connective tissue and composed principally of anaplastic cells that resemble those of supportive tissues.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

sarcoma

Pathol a usually malignant tumour arising from connective tissue
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Aboulafia, "Granulocytic sarcoma: An unusual complication of aleukemic myeloid leukemia causing spinal cord compression.
The histological examination of granulocytic sarcoma, the subtype of LC composed of neoplastic granulocytic precursors, shows a perivascular and periadnexal distribution of the infiltrate, with stromal fibrosis; neoplastic cells are usually large, with abundant eosinophilic cytoplasm and large nuclei with finely dispersed chromatin and occasional small nucleoli.
Baran, "Granulocytic sarcoma: a systematic review," American Journal of Blood Research, vol.
Granulocytic sarcoma of the breast in acute myeloid leukemia: two case reports.
Here we present a case of multiple granulocytic sarcomas with monocytic differentiation involving the skin and retroperitoneal area.
Chemotherapy and radiation therapy are usually given in the setting of isolated granulocytic sarcoma (GS) without evidence of leukemia.
INTRODUCTION: Leukemia is a hematologic malignancy with systemic manifestations and rarely presents as a focal parenchymal infiltration called as chloroma (1,2) or Granulocytic sarcoma. (3) Primary lesions that result in granulocytic sarcoma are acute myeloid leukemia(AML) acute lymphoblastic leukemia(ALL), chronic lymphocytic leukemia(CLL), and myelodysplastic syndrome(MDS) and rarely in chronic myeloid leukemia(CML).
Intraoral granulocytic sarcoma: a case report and review of the literature.
Baytan et al.'s case report entitled, Cerebellar granulocytic sarcoma: A case report (2012; 19: 177-180), (1) provides an opportunity for me to remind physicians that short-course megadose methylprednisolone (MDMP: 30 mg/kg for 3 d, then 20 mg/kg for 4 d each dose administered over the course of 10-15 min intravenously or orally; calculated dose of powder put into a spoon and then covered with honey and administered before 0600), has been effectively used for the treatment of granulocytic sarcoma (GS) (2), (3), (4), (5).

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