granulocytopenia


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granulocytopenia

[¦gran·yə·lō‚sīd·ə′pēn·yə]
(medicine)
A deficiency of granulocytes in circulating blood. Also known as granulopenia.
References in periodicals archive ?
Furthermore, higher levels of IL-17F were found in patient groups with neutropenia, granulocytopenia, and increased ESSDAI, which indicated that IL-17F was associated with pSS disease activity and severity.
Granulocytopenia: Condition in which the number or proportion of certain white blood cells (i.e., granulocytes) in the blood is lower than normal; granulocytes, which are characterized by the presence of small, enzyme-containing vesicles (i.e., granules) in the cytoplasm, are part of the innate immune system.
MDS is commonly associated with platelet dysfunction4 and refractory anaemia supplemented by various degrees of granulocytopenia and thrombocytopenia.
Etoposide, as other chemotherapy agents, has many side effects such as bone marrow suppression, granulocytopenia, thrombocytopenia [2], mucositis, moderate to severe esophagitis, hepatotoxicity, metabolic acidosis, and anemia [3].
Long term therapy of AZT can have severe side effects such as bone marrow toxicity resulting in granulocytopenia and anemia [1].
[10] reported 21 patients treated with radiation therapy and carboplatin at a dose of 300 mg/[m.sup.2] every 3 weeks and only 2 patients developed grade 3 granulocytopenia, 2 patients developed grade 3 anemia, and 1 patient developed grade 3 gastrointestinal toxicity.
This drug as other chemotherapy agents has many side effects such as bone marrow suppression, granulocytopenia, thrombocytopenia [6], and gastrointestinal toxicity such as nausea, vomiting, diarrhea, mucositis, moderate to severe esophagitis, hepatotoxicity accompanied by increase in bilirubin and hepatic enzymes, metabolic acidosis, and anemia [7].
Clinically, the patient often presents with early satiety secondary to splenomegaly, fatigue and weakness secondary to anemia, bleeding secondary to thrombocytopenia, or life threatening infection secondary to granulocytopenia. However, patients can be asymptomatic and be diagnosed incidentally in the setting of cytopenias.
The incidence of blood complications related to Clozapine including granulocytopenia (neutropenia and agranulocytosis) and leukopenia were evaluated.
Results of a randomized trial of granulocyte colony-stimulating factor in patients with infection and severe granulocytopenia. Anticancer Drugs 1996;7:392-397.
I was now able to immediately detect or distinguish anemia from other causes of pallor, thrombocytopenia-induced bruising from spousal abuse trauma, granulocytopenia, severe bacterial infections, and other significant illnesses.