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A discrete nodular lesion of inflammatory tissue in which granulation is significant.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a focal growth of inflammatory origin in the cells of young connective tissue in the form of a small node.

Granuloma develops in connection with various (most often infectious) processes (tuberculosis, syphilis, leprosy, brucellosis, tularemia, actinomycosis), with collagenic diseases (such as rheumatism), and at the sites of entry of foreign bodies. Certain granulomas have more specific names, such as the tubercle in tuberculosis and the gumma in syphilis.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Erfan, "Collagen-elastic tissue changes and vascular involvement in granuloma annulare: a review of 35 cases," Journal of Cutaneous Pathology, vol.
The overall incidence of papulonodular lesions of skin is leprosy (22.67%), erythema nodosum leprosum (20%), cutaneous tuberculosis and trichoepithelioma (8% each), Prurigo Nodularis, actinomycosis and epidermoid cyst (6.67% each), syringoma and granuloma Annulare (5.33% each), basal cell carcinoma and Jessner lymphocytic infiltrate (4% each), and metastatic carcinoma (2.67%).
The affected area may closely resemble other dermatologic conditions that can manifest as round patches or plaques such as pityriasis rosea, nummular eczema, granuloma annulare, psoriasis, tinea versicolor, and annular contact dermatitis.
A study revealed that granuloma annulare might be caused by a delayed-type hypersensitivity reaction.
English, "Etiology, diagnosis, and therapeutic management of granuloma annulare: an update," American Journal of Clinical Dermatology, vol.
* Granuloma annulare produces slowly expanding annular plaques that are not itchy and do not scale.
Granuloma annulare is often self-limiting and resolves within 2 years, although recurrence is possible.
We add to the literature 5 cases of Wolf isotopic response, manifesting as granuloma annulare with a perineurovascular and/or perifollicular pattern of inflammation and developing in a site of previous herpes zoster, and discuss the clinicopathologic findings.
BOSTON - A diagnosis of granuloma annulare "should trigger a high index of suspicion for dyslipidemia, especially among patients with generalized and annular disease," said Dr.
The histopathologic appearance was similar to the diffuse form of granuloma annulare except for the presence of the pseudorosettes.