OM is a rare aggressive intraosseous lesion derived from embryonic mesenchymal tissue associated with odontogenesis and primarily consisting of a myxomatous ground substance
with widely scattered undifferentiated spindled mesenchymal cells.
The ground substance
contains glycosaminoglycans like dermatan sulphate and hyaluronic acid, the proteoglycans like decorin and biglycan.
The simple odontogenic fibroma composed of stellate fibroblasts, in a whorled pattern mixed into a back ground of ground substance
with or without odontogenic rests.
As widely known, the Helmholtz free energy function [PSI] can be divided into different components corresponding to the ground substance
, the fibres network, and the material compressibility (see Nomenclature for notation).
Collagen fibres were dense and separated by edema and mucenous ground substance
. Based on these findings, the tumour was diagnosed as fibroma (Fig.
The stroma can be described as being composed of collagen fibrils in an aqueous background (the ground substance
Both fibrous components appear more compact because of a decrease in the voids or spaces between the fibers; the spaces resulted from a loss of ground substance
. Collagen bundles appear to unravel, and the individual elastic fibers show signs of elastolysis.
The ultrastructural study showed that the dimensional increase was largely due to increased production of amorphous ground substance
by fibroblasts, possibly resulting from an increased release of mast cells mediators.
This is known as the ground substance
, found not only in these layers of the artery but to a variable degree in and around all of the connective tissue cells of the body.
Cardiac (Figure 1E), skeletal, tongue, intestinal wall (Figure 1F), and esophagus muscles had moderate amount of ground substance
(myxedema) between muscular fibers.