growth factor


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Growth factor

Any of a group of biologically active poly-peptides which function as hormonelike regulatory signals, controlling the growth and differentiation of responsive cells. Indeed, the distinction between growth factors and hormones is frequently arbitrary and stems more from the manner of their discovery than from a clear difference in function. See Cell differentiation, Hormone

The sequence of amino acids has been determined for several growth-factor polypeptides. This information permits a number of growth factors to be placed into families, members of which have related amino acid sequences, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A second family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified. See Insulin, Protein

The stimulation of cell proliferation by several growth factors is similar in some ways to the rapid cell proliferation characteristic of tumor cells. Furthermore, the growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. It has been demonstrated that platelet-derived growth factor is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus. Some forms of cancer involve improper function of growth factors.

growth factor

[′grōth ‚fak·tər]
(aerospace engineering)
The additional weight of fuel and structural material required by the addition of 1 pound (0.45 kilogram) of payload to the original payload.
(physiology)
Any factor, genetic or extrinsic, which affects growth.
References in periodicals archive ?
The use of growth factor correlated with reduced risk of discontinuation both before 12 weeks and from weeks 12 to 24.
Groups of 50 COCs were placed into 500 [micro]l of BSA-free NCSU-23 solution with 0.57 mM cysteine, 10% porcine follicular fluid (pFF), 2.5 mM [beta]-mercaptoethanol, 10 ng/ml epidermal growth factor (EGF), 10 IU/ml human chorionic gonadotropin (hCG) and 10 IU/ml pregnant mare serum gonadotropin (PMSG) in each well of a 4-well multidish (Nunc, Roskilde, Denmark).
Expression of transforming growth factor alpha in human tissues: Immunohistochemical study and Northern blot analysis.
However, current versions of growth factors break down quickly and require a high dose to achieve a therapeutic potential.
Speaking about it, Gaharwar said, aACoeThese nanoparticles could prolong delivery of growth factors to human mesenchymal stem cells, which are commonly utilised in cartilage regeneration.aACA[yen]
Plasma fibroblast growth factor 23 concentration and iron status.
The authors have developed a novel technique for rabbit ear keloid model creation.Technique consists of giving injection of Transforming Growth Factor Beta 1, and subsequently performing skin punch excision(Nagi and Babar, 2015; Babar and Nagi, 2016, 2017).
The methods used for delivery of growth factors may be utilized for the provision of antibiotics or other antimicrobial agents which may help to prevent peri-implantitis.
Effect of advanced age on the induction by androgen or thyroid hormone of epidermal growth factor and epidermal growth factor mRNA in the submandibular glands of C57BL/6 male mice.
Results indicated that the MSCbFGF led to an increased production of growth factors that, in turn, accelerated fracture repair by stimulating blood vessel growth and differentiation of both endogenous and exogenous MSCs into osteoblasts, which are the cells that form new bone.
* Fibroblast growth factor (FGF) is an important player in the regeneration and proliferation of skin cells.

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