growth factor


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Growth factor

Any of a group of biologically active poly-peptides which function as hormonelike regulatory signals, controlling the growth and differentiation of responsive cells. Indeed, the distinction between growth factors and hormones is frequently arbitrary and stems more from the manner of their discovery than from a clear difference in function. See Cell differentiation, Hormone

The sequence of amino acids has been determined for several growth-factor polypeptides. This information permits a number of growth factors to be placed into families, members of which have related amino acid sequences, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A second family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified. See Insulin, Protein

The stimulation of cell proliferation by several growth factors is similar in some ways to the rapid cell proliferation characteristic of tumor cells. Furthermore, the growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. It has been demonstrated that platelet-derived growth factor is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus. Some forms of cancer involve improper function of growth factors.

growth factor

[′grōth ‚fak·tər]
(aerospace engineering)
The additional weight of fuel and structural material required by the addition of 1 pound (0.45 kilogram) of payload to the original payload.
(physiology)
Any factor, genetic or extrinsic, which affects growth.
References in periodicals archive ?
Replenishing four growth factors--epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)--through topical application has been shown to diminish wrinkles, improve elasticity, and restore moisture to rejuvenate aging skin.
The report reviews Connective Tissue Growth Factor (Insulin-Like Growth Factor-Binding Protein 8 or Hypertrophic Chondrocyte-Specific Protein 24) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
However, these recombinant growth factors can be extremely expensive and, perhaps more importantly, lack sufficient biological activity.
The team is investigating two new nerve growth factors.
Female offspring showed 35% higher serum insulin-like growth factor levels compared with female controls, thus suggesting a gender specific alteration in the growth hormone/insulin-like growth hormone pathway.
They are released by the pituitary gland and converted in the liver to another anti-aging hormone called Insulin Growth Factor (IGF-1) and dehydroepiandrosterone (DHEA) which is produced by the adrenal glands.
People who were more lonely and depressed had significantly lower epidermal growth factor levels, compared with people who were not particularly lonely or depressed.
Although the growth factors played a role in pushing the cells toward one tissue type or another, the scaffold was critical to the differentiation.
Zone: If it becomes widely available, growth factor will be quite expensive.
Growth factor and hedgehog signalling pathways meet in developmental systems
Nerve growth factor in standard and samples was bound to an anti-NGF mouse monoclonal antibody coated onto a BD Falcon 96-well microplate (BD Biosciences, Bedford, MA, USA).
6) In rabbits, Hashimoto et al showed that steroids suppress the formation of granulation tissue (1) by reducing vascular permeability, (2) by decreasing extravasation and the migration of inflammatory cells to the site of infection, (3) by inhibiting the production of a variety of chemotactic factors (especially complement factors and lymphocyte-derived factors), and (4) by acting on growth factors such as vascular endothelial growth factor and transforming growth factor beta.

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