This reflects the fact that the receptor was purposely designed to provide more than enough room for its guest molecule
. And it testifies to the precision with which Hucs concept of molecular design from first principles can be implemented in practice.
Similar bindings were reported for [G.sub.3.0] PAMAM dendrimers conjugated to 1-pyrene carboxaldehyde [G.sub.3.0]-PY (as guest) and HBCD (as host) complexes (42) in which the enhanced [[lambda].sub.Max] of the guest molecule
was attributed to the host-guest interactions.
CB7 was then gradually added to the guest molecule
solution and mixed by vortexing well before the fluorescence was recorded.
An amorphous state observed during the PXRD measurement of a solid dispersion of CD and a guest molecule
suggests that there is a possibility that CD and the guest molecule
formed an inclusion complex [9, 10].
Caption: Scheme 1: Procedure for encapsulating guest molecule
into metal-organic framework.
In fact along with the compatibility of size and shape between bCD host and guest molecule
the inclusion complexation also depends upon the substitution of included cavity water molecule by the less polar guest in aqueous medium.
A clathrate is a structure in which a primary molecular species (say water, or H2O) forms a crystalline 'cage' to contain a guest molecule
(methane or CH4, for example.).
The type of structure formed is dependent on the guest molecule
size, structure I hydrates are more prevalent in natural gas flows because they form with methane, ethane and carbon dioxide molecules.
All these facts are proving the encapsulation of the guest molecule
, that is, the existence of the inclusion complex.
Namely, hydrophobic micellar interior of the sodium 3[alpha],12[alpha]-dihydroxy-7-oxo-5[beta]-cholanoate micelle, between the steroid skeleton of bile acids and resveratrol, besides the hydrophobic interactions, contains additional hydrogen bonds between C7 oxo group and OH group of the guest molecule
In other words, clathrate hydrates are clathrate compounds in which the host molecule is water and the guest molecule
is typically a gas or liquid.
The new process involved introducing a guest molecule
- in this case a 'buckyball' or C60 - on to a surface patterned by an array of tetracarboxylic acid molecules.