Summary: TEHRAN (FNA)- Using genetic tools in mice, researchers say they have identified a pair of proteins that precisely control when sound-detecting cells, known as
hair cells, are born in the mammalian inner ear.
Liberman, "Postnatal maturation of auditory-nerve heterogeneity, as seen in spatial gradients of synapse morphology in the inner
hair cell area," Hearing Research, vol.
Although we have shown outer
hair cell damage in our study through SEM, the causes of ototoxicity need to be explained at the molecular level in future studies.
These genes include: Math-1, Myosin, Brn3, EPSIN and AchRa9 which are
hair cells specific genes.
Troiani, "Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer
hair cell survival in a guinea pig model of noise induced hearing loss (NIHL)," Brain Research, vol.
Type 2 diabetes alters the functional status of outer
hair cells in the cochlea.
Of the transplanted mIESCs in the scala media, 42.6 [+ or -] 5.7% were positive for the
hair cell marker myosin VIIa.
The total number of possible
hair cell bundles did not differ among groups [one-way ANOVA; F(1, 58) = 0.95, P = 0.33].
But new research reveals that supporting cells in the ear can turn into
hair cells in newborn mice.
Selective inner
hair cell loss in premature infants and cochlea pathological patterns from neonatal intensive care unit autopsies.
giant Pfizer is arguably the most advanced of the big players, with a drug in initial Phase I clinical testing trial for age-related sensorineural hearing loss that looks to enhance the function of existing
hair cells.
The cellular basis for aminoglycoside hearing loss is a destruction of cochlear
hair cells, specifically the outer
hair cells.