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The latter is particularly important for predicting Hurthle cell carcinomas, which are known to have a characteristic pattern of CNAs with almost complete genome haploidization [6].
In most haploidization experiments, spontaneous doubling of chromosome numbers is perceived as a benefit, albeit an unpredictable one.
UPDATE 428, 434 (2001) ("The haploidization and formation of artificial gametes by fusion of oocytes and non-germline cells will create gametes with potential use in reproduction.