hapten


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Related to hapten: complete antigen, Tolerogen

hapten

(immunology)
An incomplete antigen that cannot induce antibody formation by itself but can do so by coupling with a larger carrier molecule.
References in periodicals archive ?
Zhifeng, A label-free strategy for measuring the affinity between monoclonal antibody and hapten using microdialysis sampling combined with chemiluminescent detection, Biosens.
At the first epicutaneous contact (the sensitization phase), the haptens stimulate keratinocytes to express adhesion molecules (ICAM-1), proinflammatory cytokines (IL-1-[alpha], IL-1[beta], TNF-a, IL-6) and chemokines (IP-10, MCP-1, RANTES, CCL18) (15-18).
With haptens, like with KDN, the immunological response is usually achieved by chemical modification with the hapten-carrier complex (e.g., BSA-bovine serum albumin) and modifications to introduce active groups.
The encapsulation helps to overcome the solubility limitations and boosts the capture of the hapten and subsequent T cell response.
Particular example of hapten molecules is the ones comprising histamine-succinyl-glycine (HSG) motif and chelate moiety [251-253, 258] for the complexation with [sup.68]Ga.
The BaP standard, other types of PAHs, chemicals for BaP hapten and antigen synthesis, 25% glutaraldehyde solution, polyethylene glycol 20,000 (PEG 20,000), N,N-dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) were purchased from J&K Chemical (Beijing, China).
Manning et al., "Use of phosphonic acid as a generic hapten in the production of broad specificity anti-organophosphate pesticide antibody," Journal of Agricultural and Food Chemistry, vol.
Mice were stimulated with T cell-dependent antigen TNP-BSA, a 2,4,6-trinitrophenyl hapten conjugated with bovine serum albumin (50 pg per mice), solved in complete Freund's adjuvant (Sigma-Aldrich, Diegem, Belgium) by subcutaneous injection.
Because all our subjects in the 160 mg/kg/day ip/sc agmatine treated group and 80 mg/kg/day sc agmatine treated group developed similar skin lesions, we claim that agmatine act as a potent hapten in cutaneous/subcutaneous tissue.
(9) Alternatively it may act as a hapten, initiating an immune reaction that results in immune-mediated destruction of the neutrophil.
DA is a characteristic hapten with a low molar mass of 311 g/mol, and it cannot induce immune response in animal.