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By cutting off the head of Medusa, Perseus was able to resist the power of petrifaction.
The "round eyes" of the creature are reminiscent of the owl-like eyes of Athena, and the breasts of the Medusa could be symbolic of the head of Medusa that Athena wore on her breastplate.
Here we find Perseus brandishing the head of Medusa, executed in a rich, warm-toned palette of cobalt blue, green and orange that is characteristic of the Urbino workshops (Fig.