heat shock response

heat shock response

[′hēt ‚shäk ri‚späns]
(cell and molecular biology)
A cellular reaction to a stimulus such as elevated temperatures or abrupt environmental changes, in which there is cessation or slowdown of normal protein synthesis and activation of previously inactive genes, resulting in the production of heat shock proteins.
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References in periodicals archive ?
The heat shock response is commonly believed to be dominated by multiple genes.
The heat shock response in moss plants is regulated by specific calcium-permeable channels in the plasma membrane.
For example, the attempt of survival is induced by a cell in the case of the heat shock response or the unfolded proteins response leading to activation of chaperone protein that increases the ability of the protein to fold, by counteracting induced stress and so promoting the cell survival.
Research conducted at Northwestern University found that the heat shock response, which is essential for proper protein formation and cellular health, declined steeply over a period of hours that coincided with the onset of reproductive maturity in C.
Experimental demonstration of plasticity in the heat shock response of the intertidal mussel Mytilus californianus.
Metabolism, special proteins for cold adaptation, catalysis and protein folding, and the heat shock response, each get a separate chapter in this section.
In some habitats, a stress from daily or seasonal fluctuation of environmental temperature causes an organism to respond by inducing sets of proteins including heat shock proteins (HSPs) and this process is known as a heat shock response or stress response In addition to heat stress, HSPs respond to other factors such as pathogen infection, oxidative stress, heavy metals and xenobiotic stresses.
Patent Application Number 12/993,018, titled "Inducing Cell Death by Inhibiting Adaptive Heat Shock Response.
Dr Andrei Gudkov, chief scientific officer of Cleveland BioLabs, said "Inhibition of adaptive heat shock response and NF-kappaB have long been recognised as attractive targets for oncology therapeutics.
Heat shock response modulators as therapeutic tools for deseases of protein conformation.

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