Nodular glomerulosclerosis represents the most recognized manifestation of light and heavy chain
deposition disease (Figure 9, A).
The first group of M[alpha]F-Ig mAb comprised 6-B5, 6-B7, and 11-E3 and these mAb had a reactivity profile consistent with Ig heavy chain
System [y.sup.+]L consists of two subunits, a polytopic membrane protein (light chain, SLC7 family) and an associated type II membrane protein (heavy chain
, SLC3 family) subunit (Dall'Asta et al., 2000; Verrey et al., 2000; Chillaron et al., 2001).
Harbour Antibodies owns two strains of transgenic mice for generating human therapeutic antibodies: mice that generate antibodies comprised of two heavy chains
and two light chains with fully human variable regions; and mice that generate novel "heavy chain
Biogen also continues to explore the scientific value of phosphorylated neurofilament heavy chain
and will present new data on the ongoing evaluation of its potential as a biomarker in SMA.
It is an anti-vWF Nanobody, a novel class of proprietary therapeutic proteins based on single-domain antibody fragments that contain the unique structural and functional properties of naturally-occurring heavy chain
In differentiated muscle cells, ZIP14-mediated zinc accumulation induces myosin heavy chain
The heavy-chain regions (not shown) were inspected for the presence of a truncated heavy chain
as expected in heavy-chain disease; none was found, thus providing further evidence that the patient did not have [alpha]-HCD.
HLA-B*27 is one of the major histocompatibility complex (MHC) class I molecules that consist of a heavy chain
(a-chain) and [beta]-micro globulin ([beta]2m).
In addition, the HLA class I heavy chain
expression was markedly downregulated only in the two [[beta].sub.m]-negative cell lines.
In meat samples, the main protein bands identified in the range of molecular weights from 250 to 10kDa were myosin heavy chain
(MHC), [alpha]-actinin ([alpha]-act), desmin, actin (ACT), troponin T (TnT), tropomyosin (TPM), myosin light chains 1 (MLC1), troponin C (TnC), and myosin light chains 2 (MLC2).
Primary amino acid sequence analysis of the peptide fragments of HS628 and originator tocilizumab was obtained by using reduced peptide mapping followed by RP-UPLC-MS sequencing, which resulted in 100% sequence coverage for the heavy chain
and light chain of two products.