heavy chain


Also found in: Dictionary, Thesaurus, Medical, Legal, Financial, Wikipedia.
Related to heavy chain: light chain, heavy chain disease

heavy chain

[′hev·ē ′chān]
(immunology)
The heavier of the two types of polypeptide chains occurring in immunoglobulin molecules, its molecular weight range being 50,000-70,000. Also known as A chain; H chain.
References in periodicals archive ?
The antibody light chain (LC), heavy chain (HC), and ECMV IRES element were first amplified, cloned in intermediate vectors, and sequenced.
After 24 h, very small percentages of the cells treated with the extract and chromatin-modifying agents reacted with a-actinin and myosin heavy chain (2.
In conclusion, the cardiac [beta]-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in Venezuelan patients.
Wu Yuanhong, 42, was shown sitting on blankets in the narrow enclosure, his feet shackled with a heavy chain and wearing only a T-shirt and his underwear.
These techniques identify isoforms of myosin heavy chain (MHC), the protein that classifies a fiber, present in the cells.
The amino acid sequence of the dynein heavy chain was first determined by Ogawa and by Gibbons' group independently with the [beta]-chain of the outer arm dynein from sea urchin.
Human immunoglobulins are broadly classified into five major serologically different heavy chain isotypes (IgM, IgG, IgA, IgD and IgE) and two distinct light chain isotypes (Kappa and Lambda) (1).
Nikolay Mihaylov, goalkeeper of Bulgaria's national football team, was involved in a heavy chain car accident that took place on his home country's Trakiya highway, according to a media report.