helicase


Also found in: Dictionary, Medical, Wikipedia.

helicase

[′hel·ə‚kās]
(biochemistry)
An enzyme that is capable of unwinding the deoxyribonucleic acid double helix at a replication fork.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Under the deal, the firms will jointly research and develop a helicase program.
The human FANCJ helicase facilitates DNA replication through G4 forming regions and participates in DNA crosslink repair.
Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein.
Whereas Roquin destabilizes translationally inactive mRNAs by recruiting the CCR4-NOT deadenylase complex in processing- bodies (PBs) and stress granules (SGs), Regnase-1 localizes to the endoplasmic reticulum (ER) and ribosomes, destabilizes translationally active mRNAs, and requires the RNA helicase activity of UPF1, similar to NMD.
Helicase's technology can provide humans with substantial benefits ranging from better focus to more energy within a matter of weeks, he noted.
Bell et al., "A de novo frame-shift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): a case report and literature review," American Journal of Medical Genetics Part A, vol.
LGP2 is an RNA helicase, homologous in structure to RIG-I and MDA5, except that it lacks the 2CARDs that are required to initiate antiviral signaling via the MAVS adaptor protein (Figure 1(c)).
BLAST analysis performed for amino acid sequence of AltMV TGBp1 predicted the existence of N-terminal helicase domain [2].
In actual the NS3 protein of dengue virus is multifunctional enzyme, acting as protease and a helicase domain, in specific sites the protease is responsible for the survival of dengue virus.
Nevertheless, the GDS04 strain shares 95.7% aa identity with HKU2 in nonstructural protein (nsp) 3 (adenosine diphosphate-ribose 1'-phosphatase), 96.4% in nsp5 (3C-like protease), 94.6% in nspl2 (RNA-dependent RNA polymerase), 99.8% in nspl3 (helicase), 99.2% in nspl4 (3'-to-5' exonuclease), 99.4% in nspl5 (poly[U]-specific endoribonuclease), and 97.6% in nspl6 (2'-O-ribose methyltransferase).
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Peterson, Inhibition of Herpes Simplex Virus Replication by a 2-amino thiazole via Interactions with the Helicase Component of the UL5-UL8-UL52 Complex.