Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, chronic hematologic disorder
. It is an ultra-rare disease with approximately 8,000 to 10,000 cases reported in North America and Europe.
The monoclonal antibody is now the first and only drug to be approved in the US for the treatment of the hematologic disorder
The laboratory findings observed in DRESS syndrome include some hematologic disorders
. The most common hematologic disorder
is eosinophilia with rates reaching up to 95%.
In one study, 55 percent of breast amyloidosis patients had a hematologic disorder
, most commonly extranodal marginal zone B-cell lymphoma followed by plasma cell dyscrasia.
Gastroenterology team recommended upper endoscopy and considered mesenteric panniculitis reactive to underlying hematologic disorder
. Late during the course of this admission, the sent-out laboratory tests showed methylmalonic acid level of 4080nmol/L (normal range: 87-318 nmol/L), while the serologic tests for Intrinsic Factor Blocking Antibody and Anti-Gastric Parietal Cell Antibody were strongly positive.
Correction of depleted [B.sub.12] level has been associated with reversal of all hematologic abnormalities attributable to the deficiency in the absence of a concomitant hematologic disorder
as well as some of the neuropsychiatric effects it may provoke.
In up to 40% of cases, SM is accompanied by a nonmast cell hematologic disorder
(SM-AHNMD) , resulting in a combination of symptoms, related to each separate component .
The researchers have been investigating a rare disease called neutrophil-specific granule deficiency, a hematologic disorder
afflicting only a handful of people in the world.
Hemoglobinopathy is amongst the most common hereditary hematologic disorder
in country and especially in Cukurova region an important health problem.
* Hematologic disorder
(anemia, leukopenia or lymphopenia on two or more occasions, thrombocytopenia)
His physical exam was unremarkable, without splenomegaly or other findings suggestive of a hematologic disorder
. His hemoglobin level was 19.5 g/dL with a hematocrit of 58 percent.
The diagnosis of HEV infection occurred a median of 10 (range 0-227) months after identification of the hematologic disorder
. No persons in the study had traveled outside France during the year before hepatitis was diagnosed.