hemidesmosome


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Related to hemidesmosome: Adherens junction, Gap junctions

hemidesmosome

[‚hem·ē′dez·mə‚sōm]
(histology)
A structure similar to a desmosome that joins a cell to its basilar membrane rather than to another cell.
References in periodicals archive ?
Hemidesmosome formation, which was observed along the cytoplasmic extensions, and the basal lamina located around the collagen fibres and smooth muscle were demonstrated.
Investigative efforts led to the identification of an immunoglobulin G (IgG) autoantibody, which binds to bullous pemphigoid (BP) antigen 2, also called BP180, which is a protein associated with hemidesmosomes of basal keratinocytes.
We assessed, by electron microscopy, the ability of these antibodies to block laminin-5-induced hemidesmosome assembly in SCC12 cells.
proteins, in addition to intercellular junctions, hemidesmosomes, focal
It is characterized by tissue-bound autoreactive antibodies against structural proteins of the basement membrane zone and of hemidesmosomes that mediate the recruitment of inflammatory and immune cells with the generation of chronic inflammation.
It is the basic feature of cells to have an epithelial cell-like morphology and clear eosinophilic cytoplasm characterized by pre-melanosomes, hemidesmosomes and intensive cytoplasmic glycogen gathered with weak intra-cellular connections.
IgA autoantibodies react to components of the hemidesmosomes and basement membrane.
Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J.
It also becomes more prone to infections, mainly due to increased epithelial permeability and impaired barrier function secondary to the focal loss of hemidesmosomes that occurs with age [5], as well as decreased phagocytic ability of neutrophils.
BPAG1 (230 kD), proteins connecting the parts of the cytoskeleton with hemidesmosomes and desmosomes.
Pathogenesis of the disease is connected with presence of autoantibodies against antigens present in basement membrane: bullous pemphigoid antigen 2 (BPAG2, collagen XVII) whose molecular weight is 180 kD and bullous pemphigoid antigen 1 (BPAG1) with molecular weight 230 kD which are part of hemidesmosomes. It is also known that mediators excreted by mast cell play a role in development of the disease.
Under electron microscopy, well-formed desmosomes and hemidesmosomes together with pinocytic vesicles, plentiful rough endoplasmic reticulum and 6 nanometer microfilaments are seen (11).