hemizygous


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hemizygous

[¦he·mē¦zī·gəs]
(genetics)
In diploid organisms, the presence of single copy of a gene; it may be a result of deletion or chromosome loss, or simply may reflect the presence of a single copy of a sex chromosome, such as the X in male mammals.
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1] transgenic plants were expected to be either homozygous or hemizygous for the inserted transgene(s) (Fig.
Finally, deletions of one or more exons, estimated to occur at a frequency of 1%-3% in disease-causing chromosomes (35), will not be detected and could make the scanning of hemizygous variants within the deleted area more difficult.
CryIA-positive plants derived from MON 81 or MON 249, that were either homozygous or hemizygous for a cryIA insert, were analyzed in a completely randomized design.
To assess the suitability of this method for the follow-up of Gaucher and Fabry patients during therapy, we investigated samples from 4 Gaucher patients, 2 on ERT and 2 on SDT, and 2 hemizygous Fabry patients on ERT.
Finally, one primer (4%) detected three alleles in Obino l'Ewai, which may indicate a combination of both heterozygous and hemizygous forms of homoeologous loci in the A and B genomes, respectively.
The method would therefore be amenable to screening an X-linked dominant disorder with heterozygous females and hemizygous male patients.
This indicated the A fragment was hemizygous and the monosome in these plants was a P-genome chromosome.
Classically, it affects hemizygous males with no residual [alpha]-galactosidase A activity, displaying all the characteristic signs of the disease.
HIF [sup]flox/- mice were bred with muscle creatine kinase ( MCK )- Cre [sup]+ hemizygous mice to create HIF [sup]flox/- Cre [sup]+ mice.
Molecular analysis revealed two novel hemizygous mutations in the patients: a deletion mutation (c.
Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's diseasecausing dominant mutation APPsw.
Since males are hemizygous for chromosome X, only maternal haplotype analysis and fetal inheritance of the maternal X-linked mutations were performed (Fig.