In 2011, the implementation of Hospital da Crianca de Brasilia Jose Alencar (HCB) was started, through a management agreement signed between SHS-DF and the Institute of Childhood Cancer and Specialized Pediatrics (ICIPE), a Social Organization created by the Brazilian Association of Assistance to Families of Children with Cancer and Hemopathy
(ABRACE), especially for the purpose of managing HCB (26).
For the present investigation, only adult patients were included and patients who had pregnancy, cancer, hemopathy
, other kidney diseases, liver diseases, and the use of anticoagulants prior to admission were excluded.
However, successive blood cell counts showed fluctuating leukocytosis with monocytosis at the upper limit of normal, stressing out the need to rule out a hemopathy
like juvenile myelomonocytic leukemia, finally refuted.
Exclusion criterions were (i) a comorbidity of a metabolic disease, such as diabetes mellitus, gout, hyperlipidemia, or hemopathy
; (ii) pregnancy or lactation; (iii) any symptom of massive stress or acute disease in the previous 2 weeks, such as large area of burns, psychic trauma, fever, cough, vomiting, and diarrhea; and (iv) use of specific drugs during the last 2 weeks, such as antibiotics, hormones, or nonsteroid anti-inflammatory drugs.