Type 1 APP, which include AGP, complement component 3, SAA, CRP, haptoglobin and hemopexin
, are regulated by IL-1, IL-6 and TNF-[alpha] and also by glucocorticoids.
Frye et al, (19) found significant difference in 6 proteins associated with bipolar depression, mood disorders, and including unipolar, hemopexin
(HPX), growth differentiation factor 15 (GDF-15), matrix metalloproteinase-7 (MMP-7), hepsin (HPN), transthyretin (TTR), and retinol-binding protein 4 (RBP-4).
In the GO network, seven genes (C-C motif chemokine ligand 1 [CCL1], CCL23, hemopexin
, mucolipin 1, leucine zipper and EF-hand containing transmembrane protein 2, phospholipase A2 group VI [PLA2G6], and protein tyrosine phosphatase, receptor type, C [PTPRC]) were related to cellular metal ion homeostasis in seven major GO terms, and this cluster was the largest in this network.
, a heme-scavenging protein, when administered postexposure, decreases lung injury and improves survival.
Teleost Wap65 is most closely homologous to mammalian hemopexin
. Moreover, the Wap65s contain hemopexin-like domains.
Characterization of the distinct collagen binding and cleveage mechanisms of matrix metalloproteinase 2 and 14 (gelatinase A and MT1-MMP): the different roles of the MMP hemopexin
C domains and the MMP-2 fibronectin type II modules in collagen triple helicase activities.
Trisialyl di-antennary N-glycan in rat plasma hemopexin
. Glycopeptides obtained by pronase digestion of rat plasma hemopexin
contain in addition to mono- and di-sialyl diantennary constituents, a trisialyl diantennary compound, bearing three Neu5Ac residues.
In its structure, apart from the prodomain and the catalytic domain, a fibronectin-like, a hemopexin
, and a type V collagen-like domain are included .
It is estimated that of the approximate 10,000 proteins in the serum, only 21 proteins (namely, albumin; IgG; transferrin; haptoglobin; transthyretin; [alpha]2-macroglobulin; [alpha]1-antitrypsin; [alpha]-acid glycoprotein; hemopexin
; apolipoprotein A1 and B; AGP; lipoprotein A; factor H; ceruloplasmin; complements C4, C9, C19, and C8; and prealbumin) constitute >99% of the serum protein mass .
Henkel et al., "Reduced hemopexin
levels in peritoneal fluid of patients with endometriosis," Fertility and Sterility, vol.
Historical candidates as proteinuric factors include vascular permeability factor (VPF) that is synthesized by T cells  and hemopexin