Christmas disease

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Related to hemophilia B: Hemophilia C, Von Willebrand disease

Christmas disease

[′kris·məs di‚zēz]
(medicine)
A hereditary, sex-linked, hemophilia-like disease involving failure of the clotting mechanism due to a deficiency of Christmas factor. Also known as Factor IX deficiency.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In conclusion, we aimed to emphasize the difficulties in follow-up of patients with severe hemophilia B who develop allergic reaction and inhibitor against FIX concentrates.
Karim (13) reported 52.5%, & 40% as mild disease in Hemophilia A & B, moderate-47.5 % & 50% in Hemophilia A & B and 10 % in severe hemophilia B, no case has been found in Hemophilia A.
In Hemophilia B, the FIX gene is 33.5 kb long, has eight exons and codes for the FIX factor, a single chain glycoprotein (Yoshitake et al.
Even such a tiny increase in factor IX could save the lives of people with hemophilia B, who can suffer dangerous spontaneous bleeding in the joints or the brain, High says.
This report provides comprehensive information on the therapeutic development for Hemophilia B, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
4 January 2012 - Dutch human gene therapy specialist Amsterdam Molecular Therapeutics (AMS:AMT) said today its gene therapy programme for the treatment of hemophilia B had obtained US Food and Drug Administration (FDA) Orphan Drug status.
To test whether such an approach would work, Brinkhous, Woo, and their colleagues turned to a canine model - that is, dogs that produced no detectable amounts of factor IX and therefore suffered from hemophilia B.
In 2014, the 9MM had 60,671 diagnosed prevalent cases of hemophilia A and hemophilia B, around 28% of which occurred in the US.
[ClickPress, Fri Aug 07 2015] Global Markets Direct's, 'Hemophilia B - Pipeline Review, H1 2015', provides an overview of the Hemophilia B's therapeutic pipeline.