As a result, it directly activates JakSTAT pathway and causes cytokine independent proliferation of multipotent
hemopoietic progenitor uncontrolled cell growth.4,10
In our patient, the remarkable amount of blood cells precursors obstructing the brain small vessels must be ascribed to their abundance in the bone marrow of a young subject as compared to that present in elderly patients observed by other investigators [10,11] in whom the
hemopoietic tissue is largely replaced by fat [21].
Samoylova, "Origin of
hemopoietic stromal progenitor cells in chimeras," Experimental Hematology, vol.
Preautopsy clinical impression was that of a primary
hemopoietic disorder.
Hemopoietic stem/progenitor cell (HSPC) activation and retention are modulated by the bone marrow (BM) niche where they are located.
Most cases are terminal deoxynucleotidyl transferase (TdT) positive and express early
hemopoietic markers such as CD34 and HLA-DR expression15,16.
These substrates have been involved in angiogenesis, transmigration of endothelial progenitor cells (EPC), and
hemopoietic stem cells to the site of damage and initiate tissue repair.
Characteristics of the
hemopoietic abnormalities after chronic exposure to benzene.
The association of HLA antigen and GVHD in allogeneic
hemopoietic stem cell transplantation with histocompatible sibling donor: A single-center experience in Korea.
Brunangelo Falini is the head of the Institute of Hematology and
Hemopoietic Stem Cell Transplantation at the University of Perugia, Perugia, Italy.
CD34 is a cell surface, sialomucin-like glycoprotein that is expressed on
hemopoietic progenitor cells, normal vascular endothelium, and fibroblasts.
The bone marrow material showed adequate hemopoiesis in all three
hemopoietic cell lines.